1335636-34-4

Basic information

• Product Name: C₁₇H₁₆FN₃OS
• Synonyms: C₁₇H₁₆FN₃OS
• CAS NO: 1335636-34-4
• Molecular Weight: 329.398
• Mol File: 1335636-34-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₆FN₃OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₆FN₃OS(1335636-34-4)
• EPA Substance Registry System: C₁₇H₁₆FN₃OS(1335636-34-4)

Safety Data

• Hazardous Substances Data: 1335636-34-4(Hazardous Substances Data)

Upstream product

• 399-96-2 4-amino-2-fluorophenol 
• 40106-58-9 4-chloro-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3- d]pyrimidine 

Downstream Products

• 1321618-92-1 N-(3-fluoro-4-(6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 

Relevant articles and documents

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d] pyrimidine or furo[2,3-d]pyrimidine scaffold

A series of thieno[2,3-d]pyrimidines and furo[2,3-d]pyrimidines were synthesized and evaluated for the c-Met inhibition. Thieno[2,3-d]pyrimidine 6b stood out as the most potent showing an IC50 of 35.7 nM. This compound displayed high inhibitory effect on cell proliferation in BaF3-TPR-Met cells and showed high selectivity for c-Met family against other 14 tested kinases. However, compound 6b was found ineffective in the c-Met-dependent U-87MG human gliobastoma xenograft model that may be relevant to its poor PK profile.