133587-11-8

Basic information

• Product Name: 1-[4-(1,4,7,10-tetraazacyclododecan-1-ylmethyl)benzyl]-1,4,7,10-tetraazacyclododecane
• Synonyms: 1-[4-(1,4,7,10-tetraazacyclododecan-1-ylmethyl)benzyl]-1,4,7,10-tetraazacyclododecane
• CAS NO: 133587-11-8
• Molecular Weight: 446.683
• Mol File: 133587-11-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-[4-(1,4,7,10-tetraazacyclododecan-1-ylmethyl)benzyl]-1,4,7,10-tetraazacyclododecane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(1,4,7,10-tetraazacyclododecan-1-ylmethyl)benzyl]-1,4,7,10-tetraazacyclododecane(133587-11-8)
• EPA Substance Registry System: 1-[4-(1,4,7,10-tetraazacyclododecan-1-ylmethyl)benzyl]-1,4,7,10-tetraazacyclododecane(133587-11-8)

Safety Data

• Hazardous Substances Data: 133587-11-8(Hazardous Substances Data)

Usage

Explanation

The compound's full name describes its structure, which includes a benzyl group and multiple cyclic structures containing nitrogen atoms.

Explanation

This is a shorter, more commonly used name for the compound.

Explanation

CB-TE2A has multiple sites for binding to metal ions, making it a polydentate ligand.

Explanation

The compound's structure includes a benzyl group (a phenyl group attached to a methyl group) and several nitrogen-containing cyclic structures.

Explanation

CB-TE2A is used in these fields due to its ability to chelate metal ions and bind to radiometals.

Explanation

The compound can chelate these specific metal ions, which is important for its use in radiopharmaceuticals.

Explanation

Due to its unique structure and properties, CB-TE2A is valuable in the development of targeted molecular imaging agents for cancer.

Explanation

The compound's unique structure contributes to its usefulness in a range of biomedical applications.

Type of Compound

Polydentate Ligand

Structure

Benzyl group and multiple cyclic structures containing nitrogen atoms

Application

Coordination Chemistry and Radiopharmaceuticals

Metal Ion Chelation

Copper-64 and Gallium-68

Biomedical Applications

Targeted molecular imaging agents for cancer diagnosis and therapy

Unique Structure

Valuable component in various biomedical applications

Upstream product

• 94530-07-1 1,4,7-tris-(4-tolylsulphonyl)-1,4,7,10-tetraazacyclododecane 
• 175854-39-4 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane 
• 289685-84-3 1,4,7-tricarbaldehyde-1,4,7,10-tetraazacyclododecane 
• 623-24-5 1,4-bis(bromomethyl)benzene 
• 294-90-6 1,4,7,10-tetraazacyclododecan 

Downstream Products

• 1073314-28-9 1,4-bis[1-(4,7,10-tris(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane)]-p-xylene 

Relevant articles and documents

Selective mono N-alkylations of cyclen in one step syntheses

In this Letter, we describe selective one step mono N-alkylations of cyclen (1,4,7,10-tetraazacyclododecane) using a range of functionalized alkyl halides. This 'easy to use' synthesis gives rise to mono-derivatives of cyclen from various alkyl halides or

Linked cyclic polyamines with activity against hiv.

There is disclosed a pharmaceutical composition comprising as active ingredient a linked cyclic compound of general formula I,Z - R - A - R' - Y in which Z and Y are independently cyclic polyamine moieties having from 9 to 32 ring members and from 3 to 8 amine nitrogens in the ring spaced by 2 or more carbon atoms from each other, ???A is an aromatic or heteroaromatic moiety, ???R and R' are each a substituted or unsubstituted alkylene chain or heteroatom containing chain. or an acid addition salt or metal complex thereof, in admixture or association with a pharmaceutically acceptable diluent or carrier.

Expeditious N-monoalkylation of 1,4,7,10-tetraazacyclododecane (cyclen) via formamido protection

The reaction of cyclen 1 with chloral hydrate afforded exclusively 1,4,7-triformylcyclen 2 in high yield; the triprotected macrocycle was easily alkylated with various electrophiles in good to excellent yields. The alkaline removal of the formyl groups pr