133643-21-7Relevant articles and documents
Chiral aminal templates: Diastereoselective addition to hydrazones; an asymmetric synthesis of α-amino aldehydes
Alexakis,Lensen,Tranchier,Mangeney,Feneau-Dupont,Declercq
, p. 1038 - 1050 (2007/10/02)
The monohydrazone of glyoxal may be derivatized into a chiral aminal with diamine 7. The resulting chiral reagent 13 reacts with complete diastereocontrol with organolithium reagents in THF. This sterically controlled reaction may be altered to chelation