133645-46-2

Basic information

• Product Name: 3S)-Hydroxy Simvastatin
• Synonyms: [1S-[1a,6a,7b,8b(2S*,4S*),8ab]]-1,2,6,7,8,8a-hexahydro-6-hydroxy-3,7-dimethyl)-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl Ester 2,2-dimethyl-butanoic Aci;3S)-Hydroxy Simvastatin;2,2-Dimethylbutanoic Acid [1S-[1a,6a,7,8(2S*,4S*),8a]]-1,2,6,7,8,8a-Hexahydro-6-hydroxy-3,7-dimethyl)-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl Ester;3’(S)-Hydroxy Simvastatin DISCONTINUED;3-(S)-Hydroxy SiMvastatin-d3;2,2-DiMethylbutanoic Acid [1S-[1α,6α,7β,8β(2S*,4S*),8aβ]]-1,2,6,7,8,8a -Hexahydro-6-hydroxy-3,7-diMethyl)-8-[2-(tetrahydro -4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl Ester;SiMvastatin (6S)-Hydroxy IsoMer;(6S)-Hydroxy Simvastatin
• CAS NO: 133645-46-2
• Molecular Formula: C25H38O6
• Molecular Weight: 434.569
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;Heterocycles
• Mol File: 133645-46-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Refractive Index: 1.542
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3S)-Hydroxy Simvastatin(CAS DataBase Reference)
• NIST Chemistry Reference: 3S)-Hydroxy Simvastatin(133645-46-2)
• EPA Substance Registry System: 3S)-Hydroxy Simvastatin(133645-46-2)

Safety Data

• Hazardous Substances Data: 133645-46-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 133645-46-2 differently. You can refer to the following data:
1. A derivative of Simvastatin
2. A derivative of Simvastatin.

InChI:InChI=1/C25H38O6/c1-6-25(4,5)24(29)31-21-10-14(2)9-16-11-20(27)15(3)19(23(16)21)8-7-18-12-17(26)13-22(28)30-18/h9,11,15,17-21,23,26-27H,6-8,10,12-13H2,1-5H3/t15-,17-,18-,19+,20?,21?,23+/m1/s1

Upstream product

• 149949-01-9 6(S)-hydroperoxysimvastatin 
• 123049-81-0 simvastatin 

Relevant articles and documents

COMPOUND, AND SEPARATION METHOD, SYNTHESIS METHOD AND USE THEREOF

The invention relates to new compounds as well as a separation method, a synthetic method and use thereof. It is demonstrated by an assay on activity that the compound has an activity of inhibiting an HMG-CoA reductase. In addition, the invention also relates to a derivative of the compound.

Autooxidation of simvastatin

Autooxidation of the cholesterol-lowering agent simvastatin in ethylene dichloride solution with an azo-type free-radical initiator was investigated in kinetic studies using HPLC. The primary products were oligomers, with peroxide groups within the backbone chain, and some monomeric epoxides. These and several secondary products were isolated chromatographically and identified spectroscopically. A reaction scheme was proposed in which the oligomers arise from competitive hydrogen abstraction and addition reactions of oligomeric free radicals with simvastatin while the epoxides arise from homolytic peroxide cleavage.