133703-73-8

Basic information

• Product Name: Carbamic acid, [2-[(2-aminophenyl)amino]-2-oxoethyl]-, 1,1-dimethylethyl ester
• CAS NO: 133703-73-8
• Molecular Formula: C13H19N3O3
• Molecular Weight: 265.312
• Mol File: 133703-73-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-[(2-aminophenyl)amino]-2-oxoethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-[(2-aminophenyl)amino]-2-oxoethyl]-, 1,1-dimethylethyl ester(133703-73-8)
• EPA Substance Registry System: Carbamic acid, [2-[(2-aminophenyl)amino]-2-oxoethyl]-, 1,1-dimethylethyl ester(133703-73-8)

Safety Data

• Hazardous Substances Data: 133703-73-8(Hazardous Substances Data)

Upstream product

• 4530-20-5 BOC-glycine 
• 95-54-5 1,2-diamino-benzene 
• 1173706-98-3 tert-butyl 2-(2-iodophenylamino)-2-oxoethylcarbamate 
• 66866-43-1 N-(t-butoxycarbonyl)glycyl i-butyl carbonate 

Downstream Products

• 480446-87-5 {2-[({(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-methyl]-benzoimidazol-1-yl}-acetic acid ethyl ester 
• 5805-57-2 2-Aminomethylbenzimidazole 
• 873530-30-4 [2-{3-[(1-carbamoylmethyl-1H-benzoimidazol-2-ylmethyl)-carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl}-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 873530-29-1 {2-[({(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-methyl]-benzoimidazol-1-yl}-acetic acid 
• 873530-14-4 tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate 

Relevant articles and documents

Structural features and functional activities of benzimidazoles as NOD2 antagonists

NOD1 and NOD2 are pattern recognition receptors that have important roles in innate immune responses. Although their overactivation has been linked to a number of diseases, NOD2 in particular remains a virtually unexploited target in this respect, with on

An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology

Benzimidazole is a privileged, and routinely used pharmacophore in the drug discovery process. Herein, we report a mild, acid-free and one-pot synthesis of indole, alkyl and alpha-amino benzimidazoles through a novel HBTU-promoted methodology. An extensive library of indole-carboxylic acids, alkyl carboxylic acids and N-protected alpha-amino acids has been converted into the corresponding benzimidazoles in 80-99% yield. Since alpha-aminobenzimidazoles are highly useful synthons as chiral ligands for chemical catalysis, as well as for drug discovery endeavors, our reported method provides direct access to this scaffold in a simple, one-pot operation from commercially available carboxylic acids.

L-Valine-derived simple benzimidazole-based host in selective sensing of Hg(II) ions

A new and an easy-to-make simple benzimidazole-based chemosensor 1, derived from l-valine is reported. The chemosensor effectively recognises Hg 2+ ion in the open cleft in CH3CN containing 0.2% DMSO by exhibiting significant enhance