133728-24-2

Basic information

• Product Name: Carbamic acid, [6-(methoxymethylamino)-6-oxohexyl]-, 1,1-dimethylethyl ester
• CAS NO: 133728-24-2
• Molecular Formula: C13H26N2O4
• Molecular Weight: 274.36
• Mol File: 133728-24-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [6-(methoxymethylamino)-6-oxohexyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [6-(methoxymethylamino)-6-oxohexyl]-, 1,1-dimethylethyl ester(133728-24-2)
• EPA Substance Registry System: Carbamic acid, [6-(methoxymethylamino)-6-oxohexyl]-, 1,1-dimethylethyl ester(133728-24-2)

Safety Data

• Hazardous Substances Data: 133728-24-2(Hazardous Substances Data)

Upstream product

• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 128372-98-5 tert-butyl (6-oxoheptyl)carbamate 
• 446234-38-4 N⁴-acetyl{N¹-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide 
• 446234-39-5 N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide 
• 80860-42-0 tert-butyl 6-oxohexylcarbamate 
• 654637-20-4 N₄-acetyl-N₁-{6-methyl-[4-(5-N-tert-butyloxycarbonylamino)pentyl]-2-pyrimidyl}sulfanilamide 
• 654637-21-5 N₁-{6-methyl-[4-(5-N-tert-butyloxycarbonylamino)pentyl]-2-pyrimidyl}sulfanilamide 
• 944413-69-8 C₄₁H₅₄N₆O₁₀ 
• 944413-66-5 C₄₁H₅₄N₆O₁₀ 
• 944413-95-0 C₅₃H₇₈N₆O₁₀ 
• 944413-86-9 C₅₃H₇₈N₆O₁₀ 
• 944413-92-7 C₂₅H₂₈N₂O₃ 
• 944413-83-6 C₂₅H₂₈N₂O₃ 
• 944413-89-2 C₃₀H₃₆N₂O₅ 
• 944413-80-3 C₃₀H₃₆N₂O₅ 

Relevant articles and documents

Transposing molecular fluorescent switches into the near-IR: Development of luminogenic reporter substrates for redox metabolism

This study reports the development of a Nd(III)-based near-IR luminescent probe for monitoring aldo-ketoreductase (AKR) enzyme activity. We have adapted a coumarin-based reporter substrate for the AKR1C2 to a near-IR emitting format by tethering the former to a macrocyclic Nd(III) moiety via an alkyl linker. Enzymatic reduction of the ketone functionality on the coumarin alters the energy transfer efficiency from the fluorophore to the emitting lanthanide species, resulting in emission at ～1060 nm from the alcohol product. The efficiency of sensitization is not significantly affected by extending the alkyl tether from two to three carbons, and even a six-carbon linker still supports viable sensitized luminescence. In addition, the suitability of these complexes to act as enzyme substrates improves with longer linker length. We have thus developed long wavelength luminogenic reporter substrates for a redox enzyme and also a general platform for transposing molecular fluorescence into the more desirable near-IR region. Copyright

BICYCLIC AND TRICYCLIC CAP BEARING MERCAPTOACETAMIDE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

HDAC INHIBITORS

The present invention provides hydroxamic acid compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the hydroxamic acid compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of the present invention.