133735-81-6

Basic information

• Product Name: 1-benzyl-4-(diethoxymethyl)-1H-1,2,3-triazole
• Synonyms: 1-benzyl-4-(diethoxymethyl)-1H-1,2,3-triazole
• CAS NO: 133735-81-6
• Molecular Weight: 261.324
• Mol File: 133735-81-6.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-(diethoxymethyl)-1H-1,2,3-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(diethoxymethyl)-1H-1,2,3-triazole(133735-81-6)
• EPA Substance Registry System: 1-benzyl-4-(diethoxymethyl)-1H-1,2,3-triazole(133735-81-6)

Safety Data

• Hazardous Substances Data: 133735-81-6(Hazardous Substances Data)

Usage

Chemical structure

The compound has a triazole ring and a benzyl group attached to it, with two diethoxymethyl groups in its molecular structure.

Functional groups

Contains a triazole ring, benzyl group, and diethoxymethyl groups.

Molecular weight

Approximately 287.36 g/mol (calculated from the molecular formula).

Appearance

The compound is likely a solid, although the specific appearance is not provided in the material.

Solubility

The solubility of the compound is not mentioned in the material, but it may be soluble in organic solvents due to its nonpolar nature.

Stability

The stability of the compound is not explicitly mentioned, but it is likely stable under normal conditions due to its covalent bonding.

Reactivity

The compound is used as an intermediate in organic synthesis, indicating that it is reactive in various chemical reactions.

Applications

Potential applications in medicinal chemistry and material science due to its unique structure and properties.

Safety precautions

It is important to handle and store this chemical with caution as it may pose health and safety risks if not properly managed. Specific hazards are not provided in the material, but general chemical safety practices should be followed.

Upstream product

• 10160-87-9 Propiolaldehyde diethyl acetal 
• 100-39-0 benzyl bromide 
• 622-79-7 benzyl azide 

Downstream Products

• 124940-34-7 1-(phenylmethyl)-1H-1,2,3-triazole-4-carboxaldehyde 

Relevant articles and documents

Reusable polymer-supported catalyst for the [3+2] Huisgen cycloaddition in automation protocols

A polymer-supported catalyst for Huisgen's [3+2] cycloaddition reaction between azides and alkynes was prepared from copper(I) iodide and Amberlyst A-21. This catalyst was then used in an automated synthesis of 1,4-disubstituted 1,2,3-triazoles giving acc

Tandem synthesis of 1-formyl-1,2,3-triazoles

A tandem method for preparing 4-formyl-1,2,3-triazoles via a two-step one-pot acetal cleavage/CuAAC reaction was developed. Using this method, 4-formyl-1,2,3-triazole analogs with both electron-withdrawing and electron-donating substituents were prepared in good yield and purity. Expansion of this method to a three-step tandem reaction that incorporates an additional step of azide substitution was also successful, circumventing the need for organic azide isolation. This one-pot method, noteworthy in its simplicity and mild conditions, utilizes practical, readily available reactants and relies on protic solvent to promote acid-catalyzed acetal cleavage.

Copper(II) SBA-15: A reusable catalyst for azide-alkyne cycloaddition

The azide-alkyne cycloaddition reaction was investigated under catalytic conditions involving a copper(II) loaded silica based mesoporous material. Cu(II) SBA-15 demonstrated a high catalytic effect in 1,4-triazoles synthesis in organic. No additives such