133745-74-1Relevant articles and documents
Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride
Hammond, Gerald B.,Li, Wangbing,Lu, Zhichao,Xu, Bo
supporting information, p. 9640 - 9644 (2021/12/14)
An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerates nucleophilic fluorinations using easy handling KF. We also successfully converted an inexpensive and commercially available ion-exchange resin to the polymer-supported ion pair promoter (A26–SO42–), which could be reused after filtration. Moreover, A26–SO42– can be used in continuous flow conditions. In our conditions, water is well-tolerated.
SELECTIVE MONO- AND DIFLUORINATION OF ENOLATES
Differding, Edmond,Rueegg, Gabriela M.,Lang, Robert W.
, p. 1779 - 1782 (2007/10/02)
The selective transformation of enolates into mono- and difluorinated carbonyl compounds can be performed in a one-pot procedure using N-F-sultam 1.The yields and the selectivity of the fluorination strongly depend on the counterion of the enolate and the acidity of the protons α to the carbonyl group.
