133747-67-8

Basic information

• Product Name: methyl 1-(3-chlorophenyl)-5-oxopyrrolidine-3-carboxylate
• Synonyms: methyl 1-(3-chlorophenyl)-5-oxopyrrolidine-3-carboxylate
• CAS NO: 133747-67-8
• Molecular Formula: C₁₂H₁₂ClNO₃
• Molecular Weight: 253.69
• Mol File: 133747-67-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 450.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.334±0.06 g/cm3(Predicted)
• PKA: -1.99±0.40(Predicted)
• CAS DataBase Reference: methyl 1-(3-chlorophenyl)-5-oxopyrrolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-(3-chlorophenyl)-5-oxopyrrolidine-3-carboxylate(133747-67-8)
• EPA Substance Registry System: methyl 1-(3-chlorophenyl)-5-oxopyrrolidine-3-carboxylate(133747-67-8)

Safety Data

• Hazardous Substances Data: 133747-67-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 92847-41-1 1-(3-chlorophenyl)-5-oxopyrrolidine-3-carboxylic acid 
• 97-65-4 2-methylenesuccinic acid 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 133747-68-9 1-(3-Chlorophenyl)-4-hydroxymethyl-2-pyrrolidone 
• 1026916-34-6 Methanesulfonic acid 1-(3-chloro-phenyl)-5-oxo-pyrrolidin-3-ylmethyl ester 
• 133747-69-0 Methyl 4-[1-(3-chlorophenyl)-2-pyrrolidon-4-yl]methoxybenzoate 
• 1086374-92-6 1‐(3‐chlorophenyl)pyrrolidine‐3‐carboxylic acid 
• 1422385-97-4 methyl 1-(3-chlorophenyl)pyrrolidine-3-carboxylate 

Relevant articles and documents

Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups

Factor XIa (FXIa) inhibitors are promising novel anticoagulants, which show excellent efficacy in preclinical thrombosis models with minimal effects on hemostasis. The discovery of potent and selective FXIa inhibitors which are also orally bioavailable has been a challenge. Here, we describe optimization of the imidazole-based macrocyclic series and our initial progress toward meeting this challenge. A two-pronged strategy, which focused on replacement of the imidazole scaffold and the design of new P1 groups, led to the discovery of potent, orally bioavailable pyridine-based macrocyclic FXIa inhibitors. Moreover, pyridine-based macrocycle 19, possessing the phenylimidazole carboxamide P1, exhibited excellent selectivity against relevant blood coagulation enzymes and displayed antithrombotic efficacy in a rabbit thrombosis model.

NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Phenylcarboxylic acid derivatives having hetero ring

Phenylcarboxylic acid derivatives having a hetero ring in the substituent of the formula: STR1 wherein R1 is halogen, alkyl, cycloalkyl, hydroxy, alkoxy, phenoxy which has a substituent selected from halogen and alkyl, carboxyl, alkylsulfonyloxy, phenylsulfonyloxy optionally substituted by halogen, alkylsulfonyloxyalkoxy, amino, alkanoylamino, benzoylamino, alkenyloxy, phenylalkoxyalkoxy, hydroxyalkoxy, phenylalkoxy having optionally 1 to 3 substituents selected from halogen, alkyl and alkoxy, halogenoalkyl, cycloalkyloxy optionally substituted by hydroxy, alkoxy substituted by cycloalkyl having optionally hydroxy substituent, imidazolylalkyl or imidazolylalkoxy; k is 0 or 1 to 3; or (R1)k is alkylenedioxy; A is alkylene or alkylenoxy; l is 0 or 1; B is methylene or carbonyl; m is 0 or 1; D is alkylene; E is alkylene or alkenylene; n is 0 or 1; and R2 is hydrogen or alkyl, or a salt thereof, which have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of arteriosclerosis, prophylactic and treating agent of obesity, antidiabetics.