1337935-99-5

Basic information

• Product Name: C₂₀H₁₈N₂O₂
• Synonyms: C₂₀H₁₈N₂O₂
• CAS NO: 1337935-99-5
• Molecular Weight: 318.375
• Mol File: 1337935-99-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₈N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₈N₂O₂(1337935-99-5)
• EPA Substance Registry System: C₂₀H₁₈N₂O₂(1337935-99-5)

Safety Data

• Hazardous Substances Data: 1337935-99-5(Hazardous Substances Data)

Upstream product

• 333303-27-8 2-acetoxy-5-bromo-4-(diethylamino)benzaldehyde 
• 57489-51-7 5-(diethylamino)-2-formylphenyl acetate 
• 17754-90-4 4-(Diethylamino)salicylaldehyde 
• 1334143-30-4 7-bromo-6-(diethylamino)coumarin 
• 214360-46-0 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 

Relevant articles and documents

6-arylcoumarins as novel nonsteroidal type progesterone antagonists: An example with receptor-binding-dependent fluorescence

Various 6-arylcoumarin derivatives were designed and synthesized as candidate nonsteroidal type progesterone antagonists. 6-Bromocoumarin derivatives were prepared from the corresponding 4-substituted 2-acetoxy-5-bromobenzaldehyde by employing the Still-Gennari modification of the Horner-Wadsworth-Emmons olefination reaction and were converted to 6-arylcoumarins by means of Suzuki-Miyaura cross-coupling reactions. The biological activities of these coumarin derivatives were evaluated by means of alkaline phosphatase assay in the T47D human breast carcinoma cell line. Among the synthesized compounds, 36 (IC50 = 0.12 μM) and 38 (IC 50 = 0.065 μM), bearing a five-membered heterocycle, showed potent PR antagonist activity. Competitive binding assay showed that compounds 8 and 34 have potent PR binding affinity. The fluorescence of compound 8 was dependent on the solvent properties and was increased in the presence of PR ligand binding domain. This property might be applicable to the development of fluorescence probes for studies on PR.