1337971-33-1

Basic information

• Product Name: 2-ethyl-7-mercapto-4H-chromen-4-one
• CAS NO: 1337971-33-1
• Molecular Weight: 206.265
• Mol File: 1337971-33-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-ethyl-7-mercapto-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethyl-7-mercapto-4H-chromen-4-one(1337971-33-1)
• EPA Substance Registry System: 2-ethyl-7-mercapto-4H-chromen-4-one(1337971-33-1)

Safety Data

• Hazardous Substances Data: 1337971-33-1(Hazardous Substances Data)

Upstream product

• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 137215-31-7 2-ethyl-7-hydroxy-4H-chromen-4-one 
• 1337971-31-9 S-2-ethyl-4-oxo-4H-chromen-7-yl dimethylcarbamothioate 
• 1337971-29-5 O-2-ethyl-4-oxo-4H-chromen-7-yl dimethylcarbamothioate 

Relevant articles and documents

Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity

Six 3′R,4′R-di-O-(S)-camphanoyl-2′,2′- dimethyldihydropyrano[2,3-f]chromone (DCP) and two 3′R,4′R-di-O-(S)- camphanoyl-(+)-cis-khellactone (DCK) derivatives were designed, synthesized, and evaluated for inhibition of HIV-1NL4-3 replication in TZM-bl cells. 2-Ethyl-2′-monomethyl-1′-oxa- and -1′-thia-DCP (5a, 6a), as well as 2-ethyl-1′-thia-DCP (7a) exhibited potent anti-HIV activity with EC50 values of 30, 38 and 54 nM and therapeutic indexes of 152.6, 48.0 and 100.0, respectively, which were better than or comparable to those of the lead compound 2-ethyl-DCP in the same assay. 4-Methyl-1′-thia-DCK (8a) also showed significant inhibitory activity with an EC50 of 128 nM and TI of 237.9.