1338248-67-1

Basic information

• Product Name: 3-(4-methylphenyl)-imidazo[1,2-a]pyridine
• Synonyms: 3-(4-methylphenyl)-imidazo[1,2-a]pyridine
• CAS NO: 1338248-67-1
• Molecular Weight: 208.263
• Mol File: 1338248-67-1.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 3-(4-methylphenyl)-imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)-imidazo[1,2-a]pyridine(1338248-67-1)
• EPA Substance Registry System: 3-(4-methylphenyl)-imidazo[1,2-a]pyridine(1338248-67-1)

Safety Data

• Hazardous Substances Data: 1338248-67-1(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 101671-00-5 (E)-2-(4-methylphenyl)-1-nitroethene 
• 274-87-3 tetrazolo[1,5-a]pyridine 
• 766-97-2 4-n-methylphenylacetylene 
• 274-76-0 imidazo[1,2-a]pyridine 
• 624-31-7 4-tolyl iodide 
• 106-43-4 para-chlorotoluene 
• 6200-60-8 imidazo[1,2-a]pyridine-3-carboxylic acid 
• 108-88-3 toluene 
• 1453089-69-4 C₁₅H₁₂I⁽¹⁺⁾*C₂F₃O₂^(1-) 
• 106-38-7 para-bromotoluene 
• 33491-05-3 1-(2-bromoethynyl)-4-methylbenzene 
• 60512-56-3 1-(2,2-dibromovinyl)-4-methylbenzene 

Relevant articles and documents

Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors

The FLT3 kinase represents an attractive target to effectively treat AML. Unfortunately, no FLT3 targeted therapeutic is currently approved. In line with our continued interests in treating kinase related disease for anti-FLT3 mutant activity, we utilized pioneering synthetic methodology in combination with computer aided drug discovery and identified low molecular weight, highly ligand efficient, FLT3 kinase inhibitors. Compounds were analyzed for biochemical inhibition, their ability to selectively inhibit cell proliferation, for FLT3 mutant activity, and preliminary aqueous solubility. Validated hits were discovered that can serve as starting platforms for lead candidates.

On water direct arylation of imidazo[1,2-a]pyridines with aryl halides

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Cobalt-Catalyzed Direct Arylation of Imidazo[1,2-a]pyridine with Aryl Iodides

The Co(II)Cl2·6H2O catalyzed C–H activation/direct arylation of imidazo[1,2-a]pyridine with aryl/heteroaryl iodide is reported. The cost effective, ligand and additive free protocol using KOAc successfully afforded 3-arylimidazo[1,2-

Metal-free, base catalyzed oxidative amination and denitration reaction: Regioselective synthesis of 3-arylimidazo[1,2-a]pyridines

A metal-free, regioselective strategy for the synthesis of 3-arylimidazo[1,2-a]pyridines from β-nitrostyrenes and 2-aminopyridines using triethylamine as the catalyst and H2O2 (30% aq.) as the oxidant is reported. The use of an inexp