1338248-70-6

Basic information

• Product Name: Imidazo[1,2-a]pyridine, 6-methyl-3-phenyl-
• CAS NO: 1338248-70-6
• Molecular Formula: C14H12N2
• Molecular Weight: 208.263
• Mol File: 1338248-70-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Imidazo[1,2-a]pyridine, 6-methyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridine, 6-methyl-3-phenyl-(1338248-70-6)
• EPA Substance Registry System: Imidazo[1,2-a]pyridine, 6-methyl-3-phenyl-(1338248-70-6)

Safety Data

• Hazardous Substances Data: 1338248-70-6(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 36172-53-9 N,N-dimethyl-N′-(5-methylpyridin-2-yl)formimidamide 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 6635-32-1 6-methyltetrazolo[1,5-a]pyridine 
• 536-74-3 phenylacetylene 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 5153-67-3 nitrostyrene 
• 122-78-1 phenylacetaldehyde 
• 108-90-7 chlorobenzene 
• 874-38-4 6-methylimidazo[1,2-a]pyridine 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 7436-90-0 2,2-dibromostyrene 

Relevant articles and documents

Facile synthesis of 3-substituted imidazo[1,2-: A] pyridines through formimidamide chemistry

A facile entry to 3-aryl/alkenyl/alkynyl substituted imidazo[1,2-a]pyridines (3a-p, 6a-d & 9a-9e) has been developed from readily available benzyl/allyl/propargyl halides and 2-amino pyridines as substrates via formimidamide chemistry that is devoid of caustic or expensive reagents, such as transition metal complexes. Quantum chemical calculations performed to understand the underlying mechanism of the transformation revealed a preference for intramolecular Mannich-type addition over pericyclic 1,5-electrocyclization for the systems reported herein that enable a Baldwin allowed 5-exo-trig cyclization instead of a formally anti-Baldwin 5-endo-trig process.

Metal-free, base catalyzed oxidative amination and denitration reaction: Regioselective synthesis of 3-arylimidazo[1,2-a]pyridines

A metal-free, regioselective strategy for the synthesis of 3-arylimidazo[1,2-a]pyridines from β-nitrostyrenes and 2-aminopyridines using triethylamine as the catalyst and H2O2 (30% aq.) as the oxidant is reported. The use of an inexp

An arylation method for imidazo[1,2-a]pyridine

An arylation method for imidazo[1,2-a]pyridine is provided. Under nitrogen protection, the imidazo[1,2-a]pyridine shown as a formula (1), an aryl/heterocyclic aryl chloride shown as a formula (2), a catalyst that is a N-heterocyclic carbene-palladium complex, an alkaline compound and a reaction solvent are mixed and reacted at 80-150 DEG C for 12-24 h, and then a reaction solution is subjected to after-treatment to obtain a product that is arylated imidazo[1,2-a]pyridine shown as a formula (3). A novel catalyst system is developed. The catalyst is stable and easily available, and can allow the stable and cheap aryl/heterocyclic aryl chlorides to participate a reaction. The method has advantages of simple reaction operation, a low cost, a high product yield, high purity, and the like, is a novel method for synthesizing arylated imidazo[1,2-a]pyridine compounds, provides a novel route for synthesis of the compounds, and has good research value and a good industrial application prospect.