1338468-85-1

Basic information

• Product Name: C₂₁H₂₄N₂O₂
• CAS NO: 1338468-85-1
• Molecular Weight: 336.434
• Mol File: 1338468-85-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₄N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₄N₂O₂(1338468-85-1)
• EPA Substance Registry System: C₂₁H₂₄N₂O₂(1338468-85-1)

Safety Data

• Hazardous Substances Data: 1338468-85-1(Hazardous Substances Data)

Upstream product

• 92-67-1 4-phenylalanine 
• 3365-81-9 biphenyl-4-yl-methyl-amine 
• 347-37-5 2,2,2-trifluoro-4'-phenylacetanilide 
• 1291779-66-2 N-(biphenyl-4-yl)-N-methyl-2,2,2-trifluoro-acetamide 
• 220497-67-6 (1S,3R)-3-amino-N-(9H-fluoren-9-yl)methyloxycarbonylcyclopentanecarboxylic acid 

Relevant articles and documents

Discovery of BI 99179, a potent and selective inhibitor of type i fatty acid synthase with central exposure

Based on a high-throughput screen, cyclopentanecarboxanilides were identified as a new chemotype of non-covalent inhibitors of type I fatty acid synthase (FAS). Starting from initial hits we aimed at generating a tool compound suitable for the in vivo validation of FAS as a therapeutic target. Optimisation yielded BI 99179 which is characterised by high potency, remarkably high selectivity and significant exposure (both peripheral and central) upon oral administration in rats.