1338578-37-2Relevant articles and documents
First total syntheses of 1,3-disubstituted β-carboline alkaloids, dichotomide I and marinacarbolines A-D
Tagawa, Shinji,Choshi, Tominari,Okamoto, Asuka,Nishiyama, Takashi,Watanabe, Shiroh,Hatae, Noriyuki,Hibino, Satoshi
, p. 357 - 367 (2013)
The first total syntheses of dichotomide I (1), and marinacarbolines A-D (3-6) were achieved in four steps from methyl 1-chloro-β-carboline-3- carboxlyate (9), which was previously used as a synthetic intermediate of dichotomine C. The required compound 9 was prepared in a six-step sequence including a microwave-assisted thermal electrocyclic reaction of a 1-azahexatriene system.
An efficient synthesis method targeted to marine alkaloids marinacarbolines A-D and their antitumor activities
Li, Jun,Tang, Yang,Jin, Hui-Juan,Cui, Yi-Di,Zhang, Li-Juan,Jiang, Tao
, p. 299 - 305 (2015/09/02)
Marinacarbolines A-D are a series of marine β-carboline alkaloids isolated from actinomycete Marinactinospora thermotolerans of the deep South China Sea with antiplasmodial activities. In inhibition assays of in vitro growth of Plasmodium falciparum, marinacarbolines exhibited antiplasmodial activity against drug-sensitive line 3D7 and drug-resistant line Dd2 of P. falciparum. However, approaches for the synthesis of such useful compounds are very limited. In this work, we reported a simple, efficient, and versatile process to synthesize marinacarbolines A-D (1-4). On the basis of that, the antitumor activities of marinacarbolines in a structure-dependent manner were allowed to be unveiled.
