13387-49-0

Basic information

• Product Name: Naphthalene, 1,4-dihydro-1-phenyl-
• CAS NO: 13387-49-0
• Molecular Formula: C16H14
• Molecular Weight: 206.287
• Mol File: 13387-49-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Naphthalene, 1,4-dihydro-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Naphthalene, 1,4-dihydro-1-phenyl-(13387-49-0)
• EPA Substance Registry System: Naphthalene, 1,4-dihydro-1-phenyl-(13387-49-0)

Safety Data

• Hazardous Substances Data: 13387-49-0(Hazardous Substances Data)

Upstream product

• 91-20-3 naphthalene 
• 71-43-2 benzene 
• 16939-57-4 (E)-buta-1,3-dienylbenzene 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 14371-10-9 (E)-3-phenylpropenal 
• 1187323-16-5 cis-(2R,4R)-4-phenyltetral-2-yl tosylate 
• 124-40-3 dimethyl amine 
• 605-02-7 1-phenylnaphthalene 
• 82645-20-3 (1aS*,6aR*)-1a-phenyl-1,1a,6,6a-tetrahydrocyclopropa[a]indene 
• 85803-90-3 endo-4-phenylbenzobicyclo<3.1.0>hex-2-ene 
• 85803-90-3 exo-4-phenylbenzobicyclo<3.1.0>hex-2-ene 
• 7469-40-1 1-phenyl-3,4-dihydronaphthalene 
• 16606-46-5 1-phenyl-1,2-dihydronaphtalene 
• 67-56-1 methanol 

Downstream Products

• 605-02-7 1-phenylnaphthalene 

Relevant articles and documents

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Palladium-Catalyzed Dearomative syn-1,4-Carboamination with Grignard Reagents

A protocol for palladium-catalyzed dearomative functionalization of simple, nonactivated arenes with Grignard reagents has been established. This one-pot method features a visible-light-mediated [4+2] cycloaddition between an arene and an arenophile, and subsequent palladium-catalyzed allylic substitution of the resulting cycloadduct with a Grignard reagent. A variety of arenes and Grignard reagents can participate in this process, forming carboaminated products with exclusive syn-1,4-selectivity. Moreover, the dearomatized products are amenable to further elaborations, providing functionalized alicyclic motifs and pharmacophores. For example, naphthalene was converted into sertraline, one of the most prescribed antidepressants, in only four operations. Finally, this process could also be conducted in an enantioselective fashion, as demonstrated with the desymmetrization of naphthalene.

New approach to 4-phenyl-β-aminotetralin from 4-(3-halophenyl)tetralen-2-ol phenylacetate

Mixed trifluoroacetyl phenylacetyl anhydride and 3-halostyrenes (fluoro, chloro, and bromo) or vinylcycloalkanes (cyclohexyl and cyclooctyl), undergo cascade Friedel-Crafts cycli-acylalkylation, enolization, and O-acylation to give 4-substituted tetralen-