133909-85-0

Basic information

• Product Name: 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde
• CAS NO: 133909-85-0
• Molecular Weight: 437.904
• Mol File: 133909-85-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde(133909-85-0)
• EPA Substance Registry System: 2-butyl-4-chloro-1-<<2'-(5-fluoro-1,2,3-triazol-4-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde(133909-85-0)

Safety Data

• Hazardous Substances Data: 133909-85-0(Hazardous Substances Data)

Upstream product

• 133910-07-3 5-fluoro-4-(4'-methylbiphenyl-2-yl)-1,2,3-triazole 
• 79047-41-9 2-n-butyl-4-chloro-5-hydroxymethylimidazole 
• 83857-96-9 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde 

Relevant articles and documents

Nonpeptide Angiotensin II Receptor Antagonists: The Discovery of a Series of N-(Biphenylylmethyl)imidazoles as Potent, Orally Active Antihypertensives

A new series of nonpeptide angiotensin II (AII) receptor antagonists has been prepared.These N-(biphenylylmethyl)imidazoles, e.g. 2-butyl-1--4-chloro-5-(hydroxymethyl)imidazole, differ from the previously reported N-(benzamidobenzyl)imidazoles and related compounds in that they produce a potent antihypertensive effect upon oral administration; the earlier series generally were active only when administered intravenously.It has been found that the acidic group at the 2'-position of the biphenyl is essential.Only ortho-substituted acids possess both high affinity for the AII receptor and good oral antihypertensive potency.The carboxylic acid group has been replaced with a variety of acidic isosteres, and the tetrazole ring has been found to be the most effective.The tetrazole derivative, DuP 753, is currently in development for the treatment of hypertension.