133910-48-2

Basic information

• Product Name: 2-amino-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester
• Synonyms: 2-amino-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester
• CAS NO: 133910-48-2
• Molecular Weight: 233.227
• Mol File: 133910-48-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester(133910-48-2)
• EPA Substance Registry System: 2-amino-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester(133910-48-2)

Safety Data

• Hazardous Substances Data: 133910-48-2(Hazardous Substances Data)

Upstream product

• 2899-60-7 Cbz-Gly-ONSuc 

Downstream Products

• 883865-40-5 2-(2-methyl-benzylamino)-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester 
• 883865-33-6 4-oxo-2-(2-trifluoromethyl-benzylamino)-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester 
• 883865-43-8 2-(4-methyl-benzylamino)-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester 
• 883865-29-0 2-(cyclopropanecarbonyl-amino)-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester 
• 883865-31-4 2-(2-chloro-4-fluoro-benzylamino)-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester 
• 883865-46-1 2-(2,4-dimethyl-benzylamino)-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester 
• 883865-37-0 2-[(3-methyl-thiophene-2-carbonyl)-amino]-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester 
• 883865-22-3 C₁₈H₁₆ClN₃O₃ 
• 883865-35-8 2-(2,4-bis-trifluoromethyl-benzylamino)-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester 
• 883865-24-5 2-tert-butoxycarbonylamino-4-oxo-4,5-dihydro-imidazole-1-carboxylic acid benzyl ester 
• 503-86-6 2-imino-imidazolidin-4-one 

Relevant articles and documents

Synthesis and Anticonvulsant Activity of 2-Iminohydantoins

Iminohydantoins selectively substituted at position C-5 and their 1-carbobenzoxy derivatives have been synthesized, and their anticonvulsant activity was evaluated in mice.In general, the more lipophilic 1-carbobenzoxy iminohydantoins were more potent than the unsubstituted counterparts.Evaluation of the individual enantiomers of the chiral iminohydantoins showed that the anticonvulsant activity resided primarily in the S isomers.In this study, (S)-(+)-1-carbobenzoxy-5-isobutyl-2-iminohydantoin (9a) was the most active member.This compound was not nearly as active as phenythoin against electrically induced convulsions, but was also active against pentylenetetrazole-induced seizures, suggesting a broader clinical potential.The closest analogue of phenytoin, viz., 5,5-diphenyl-2-iminohydantoin (1), failed to show any significant activity.Methylation on N-3 or the imino nitrogen of 1 also did not provide a compound with substantial activity. 2-Thiophenytoin was not active against electoshock seizures and showed only a weak activity against pentylenetetrazole.This study suggested that the structure-activity relationship of 2-iminohydantoins was quite different from that of 2-hydantoins.