133992-84-4

Basic information

• Product Name: (S)-3-Phenyl-2-[(S)-3-phenyl-2-((Z)-4,4,4-trifluoro-3-oxo-but-1-enylamino)-propionylamino]-propionic acid methyl ester
• Synonyms: (S)-3-Phenyl-2-[(S)-3-phenyl-2-((Z)-4,4,4-trifluoro-3-oxo-but-1-enylamino)-propionylamino]-propionic acid methyl ester
• CAS NO: 133992-84-4
• Molecular Weight: 448.442
• Mol File: 133992-84-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-3-Phenyl-2-[(S)-3-phenyl-2-((Z)-4,4,4-trifluoro-3-oxo-but-1-enylamino)-propionylamino]-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Phenyl-2-[(S)-3-phenyl-2-((Z)-4,4,4-trifluoro-3-oxo-but-1-enylamino)-propionylamino]-propionic acid methyl ester(133992-84-4)
• EPA Substance Registry System: (S)-3-Phenyl-2-[(S)-3-phenyl-2-((Z)-4,4,4-trifluoro-3-oxo-but-1-enylamino)-propionylamino]-propionic acid methyl ester(133992-84-4)

Safety Data

• Hazardous Substances Data: 133992-84-4(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 133992-79-7 3-phenyl-2-[(Z)-4,4,4-trifluoro-3-oxo-1-butenylamino]propanoic acid 

Downstream Products

• 38017-65-1 methyl L-phenylalanyl-L-phenylalaninate hydrochloride salt 

Relevant articles and documents

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one as a new protecting reagent in peptide synthesis

The 4,4,4-trifluoro-3-oxo-1-butenyl group is proposed as a suitable protecting group for the protection of the N-H terminal of amino acids in peptide synthesis. Amino acids react with 4-ethoxy-1,1,1-trifluoro-3-buten-2-one to give the N-protected amino acids, the protecting group can be removed by acidic hydrolysis. The formation of peptide bonds using on N-4,4,4-trifluoro-3-oxo-1-butenyl protected amino acids occurs without racemization.