134-80-5
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Basic information
- Product Name: Amfepramone hydrochloride
- Synonyms: Moderatan;Tenapil;Diethylpropion Hydrochloride CIV (200 mg);Diethylcathinone (hydrochloride);1-Propanone,2-(diethylaMino)-1-phenyl-, hydrochloride (1:1);Diethylpropion hydrochloride solution ;DIETHYLPROPION HYDROCHLORIDE;2-(DIETHYLAMINO)PROPIOPHENONE HYDROCHLORIDE
- CAS NO:134-80-5
- Molecular Formula: C13H19NO*ClH
- Molecular Weight: 241.76
- EINECS: 205-156-5
- Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
- Mol File: 134-80-5.mol
- Article Data: 0
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Chemical Properties
- Melting Point: 180-1810C
- Boiling Point: 292°Cat760mmHg
- Flash Point: 9℃
- Appearance: /
- Density: 0.972g/cm3
- Vapor Pressure: 0.00189mmHg at 25°C
- Refractive Index: N/A
- Storage Temp.: Controlled Substance, -20°C Freezer
- Solubility: N/A
- CAS DataBase Reference: Amfepramone hydrochloride(CAS DataBase Reference)
- NIST Chemistry Reference: Amfepramone hydrochloride(134-80-5)
- EPA Substance Registry System: Amfepramone hydrochloride(134-80-5)
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Safety Data
- Hazard Codes: F,T
- Statements: 11-23/24/25-39/23/24/25-20/21/22
- Safety Statements: 7-16-36/37-45-36
- RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany: 1
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 134-80-5(Hazardous Substances Data)
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134-80-5 Usage
Description
Amfepramone hydrochloride, also known as diethylpropion hydrochloride or 1-phenyl-2-diethylaminopropan-1-one hydrochloride, is a central stimulant and indirect-acting sympathomimetic. It is an appetite depressant with fewer sympathomimetic, cardiovascular, and CNS stimulatory effects than amphetamine due to its two large N-alkyl substituents. Amfepramone hydrochloride is an off-white solid and is used as an anoretic in the short-term management of obesity.Uses
Used in Pharmaceutical Industry:Amfepramone hydrochloride is used as a controlled substance (stimulant) for the treatment of obesity in patients with hypertension and cardiovascular disease. It functions as an anorexiant agent, reducing appetite and aiding in weight loss.
Used in Research and Development:
Amfepramone hydrochloride is used as a research compound to study its effects on appetite suppression and potential applications in the development of new obesity treatments. Its chemical properties and mechanisms of action provide valuable insights for the pharmaceutical industry in creating more effective and safer medications for weight management.
Originator
Tenuate,Merrell National ,US,1959Manufacturing Process
1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.Therapeutic Function
AnorexicCheck Digit Verification of cas no
The CAS Registry Mumber 134-80-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.Calculate Digit Verification of CAS Registry Number 134-80:
(5*1)+(4*3)+(3*4)+(2*8)+(1*0)=45
45 % 10 = 5
So 134-80-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H19NO.ClH/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12;/h6-11H,4-5H2,1-3H3;1H