134019-73-1

Basic information

• Product Name: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE
• Synonyms: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE;(2-Chlorosulfonyl-ethyl)-carbaMic acid tert-butyl ester
• CAS NO: 134019-73-1
• Molecular Formula: C₇H₁₄ClNO₄S
• Molecular Weight: 243.70836
• Mol File: 134019-73-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 337.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.290±0.06 g/cm3(Predicted)
• PKA: 11.17±0.46(Predicted)
• CAS DataBase Reference: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE(134019-73-1)
• EPA Substance Registry System: TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE(134019-73-1)

Safety Data

• Hazardous Substances Data: 134019-73-1(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE is a chemical compound with the molecular formula C8H15ClNOSO3. It is a carbamate derivative that contains a tert-butyl group and a chlorosulfonyl group attached to an ethyl carbamate moiety. TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized as a reagent in organic chemistry reactions, particularly in the preparation of carbamate derivatives. TERT-BUTYL 2-(CHLOROSULFONYL)ETHYLCARBAMATE has potential applications in various industries, including medicine, agriculture, and chemical manufacturing.

Upstream product

• 67385-10-8 di-tert-butyl(disulfanediylbis(ethane-2,1-diyl))dicarbamate 
• 168984-74-5 tetrabutylammonium 2-((tert-butoxycarbonyl)amino)ethane-1-sulfonate salt 
• 24424-99-5 di-tert-butyl dicarbonate 
• 67385-09-5 2-[(tert-butoxycarbonyl)amino]-1-ethanethiol 
• 122234-46-2 2-iodo-1-<(tert-butyloxycarbonyl)amino>ethane 
• 107-35-7 Tau 

Downstream Products

• 168984-76-7 [2-(2-Benzylsulfamoyl-ethylsulfamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 168984-75-6 (2-Benzylsulfamoyl-ethyl)-carbamic acid tert-butyl ester 
• 148200-69-5 N-(tert-butyloxycarbonyl)amino-ethane-sulfonyl-phenylalanine-methylester 
• 213740-69-3 3,5-Bis-[(2-tert-butoxycarbonylamino-ethanesulfonylamino)-methyl]-benzoic acid methyl ester 
• 1476070-53-7 C₁₅H₂₀F₃NO₅S 

Relevant articles and documents

Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin

Using Boc or Fmoc-protected β-substituted aminoethanesulfonyl chlorides (2-substituted taurylchlorides) the solid-phase synthesis of dipeptidosulfonamides as well as peptidosulfonamide containing peptides derived from Leu-enkephalin is described. The binding activity of the peptidosulfonamide YGGFL derivatives is reported.

Helical Antimicrobial Sulfono-γ-AApeptides

Host-defense peptides (HDPs) such as magainin 2 have emerged as potential therapeutic agents combating antibiotic resistance. Inspired by their structures and mechanism of action, herein we report the first example of antimicrobial helical sulfono-γ-AApeptide foldamers. The lead molecule displays broad-spectrum and potent antimicrobial activity against multi-drug-resistant Gram-positive and Gram-negative bacterial pathogens. Time-kill studies and fluorescence microscopy suggest that sulfono-γ-AApeptides eradicate bacteria by taking a mode of action analogous to that of HDPs. Clear structure-function relationships exist in the studied sequences. Longer sequences, presumably adopting more-defined helical structures, are more potent than shorter ones. Interestingly, the sequence with less helical propensity in solution could be more selective than the stronger helix-forming sequences. Moreover, this class of antimicrobial agents are resistant to proteolytic degradation. These results may lead to the development of a new class of antimicrobial foldamers combating emerging antibiotic-resistant pathogens.

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

INHIBITORS OF LYSINE BIOSYNTHESIS VIA THE DIAMINOPIMELATE PATHWAY

The present invention relates to compounds that have the ability to inhibit lysine biosynthesis via the diaminopimelate pathway in certain organisms. As a result of this activity these compounds can be used in applications where inhibition of lysine biosynthesis is useful. Applications of this type include the use of the compound as herbicides and/or anti-bacterial agents.