1340542-31-5Relevant articles and documents
Total synthesis of haminol A: An analysis of vinylpyridine metathesis reactivity
Storvick, Jennifer M.,Ankoudinova, Evgenia,King, Brianne R.,Van Epps, Heather,O'Neil, Gregory W.
, p. 5858 - 5861 (2011)
The total synthesis of haminol A has been completed featuring a masked-alkene metathesis reaction followed by bis-acyloxysulfone elimination to install the 1,3,8-triene subunit. During the course of our synthesis, the metathesis reactivity of 3-vinylpyridine was evaluated and our data suggest the rapid formation of a ruthenium pyridylalkylidene that no longer participates in productive metathesis. A chemotaxis assay using Caenorhabditis elegans demonstrated that haminol A produced an avoidance response from this organism.