1341179-10-9

Basic information

• Product Name: diethyl 1-ethyl-4-(4-fluorophenyl)-7-methyl-6,6-diphenyl-6,7-dihydro-1H-azepine-2,3-dicarboxylate
• CAS NO: 1341179-10-9
• Molecular Weight: 527.636
• Mol File: 1341179-10-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl 1-ethyl-4-(4-fluorophenyl)-7-methyl-6,6-diphenyl-6,7-dihydro-1H-azepine-2,3-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 1-ethyl-4-(4-fluorophenyl)-7-methyl-6,6-diphenyl-6,7-dihydro-1H-azepine-2,3-dicarboxylate(1341179-10-9)
• EPA Substance Registry System: diethyl 1-ethyl-4-(4-fluorophenyl)-7-methyl-6,6-diphenyl-6,7-dihydro-1H-azepine-2,3-dicarboxylate(1341179-10-9)

Safety Data

• Hazardous Substances Data: 1341179-10-9(Hazardous Substances Data)

Upstream product

• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 116308-58-8 diethyl (2E)-2-(diethylamino)but-2-enedioate 
• 1192167-43-3 1,1-diphenyl-3-p-fluorophenylpropargyl alcohol 

Relevant articles and documents

Lewis acid-promoted three-component reactions of propargylic alcohols with 2-butynedioates and secondary amines

We report herein a three-component reaction of propargylic alcohols with 2-butynedioates and secondary amines, which furnished functionalized dihydroazepines. In the cases where benzylmethylamine and benzyl-i-propylamine were used as the secondary amine, the reaction afforded 2,5-dihydro-1H-pyrroles and 2,3-dihydro-1H-pyrroles, respectively, as the major product along with the desired dihydroazepines. The reaction mode depends on the electronic and steric effect of the substitutents on the secondary amines used. A tentative mechanism for this cascade process is postulated. The key intermediate is ascribed to 1,3,4-pentatrien-1-amine, which is formed by trapping the in situ generating allenic carbocation with enamine. Because of the reactivity of 1,3,4-pentatrien-1-amine formed, different products were thus formed.