1341199-24-3

Basic information

• Product Name: N-[4-(aminosulfonyl)-2-methylphenyl]-2-(4-chloro-2-aminophenoxy)acetamide
• Synonyms: N-[4-(aminosulfonyl)-2-methylphenyl]-2-(4-chloro-2-aminophenoxy)acetamide
• CAS NO: 1341199-24-3
• Molecular Weight: 369.829
• Mol File: 1341199-24-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[4-(aminosulfonyl)-2-methylphenyl]-2-(4-chloro-2-aminophenoxy)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(aminosulfonyl)-2-methylphenyl]-2-(4-chloro-2-aminophenoxy)acetamide(1341199-24-3)
• EPA Substance Registry System: N-[4-(aminosulfonyl)-2-methylphenyl]-2-(4-chloro-2-aminophenoxy)acetamide(1341199-24-3)

Safety Data

• Hazardous Substances Data: 1341199-24-3(Hazardous Substances Data)

Upstream product

• 344443-67-0 ethyl 4-chloro-2-nitrophenoxyacetate 
• 89-64-5 p-chloro-o-nitrophenol 
• 1341199-23-2 N-[4-(aminosulfonyl)-2-methylphenyl]-2-(4-chloro-2-nitrophenoxy)acetamide 
• 75263-82-0 C₈H₅Cl₂NO₄ 
• 21086-49-7 (4-chloro-2-nitro-phenoxy)-acetic acid 
• 53297-70-4 4-amino-3-methylbenzenesulfonamide 

Downstream Products

• 1416363-87-5 C₂₃H₂₂ClN₃O₅S 
• 1416363-88-6 C₂₃H₂₂ClN₃O₅S 
• 1416363-89-7 C₂₃H₂₂ClN₃O₅S 
• 1416363-92-2 C₂₂H₁₉ClN₄O₇S 
• 1416363-93-3 C₂₂H₁₉ClN₄O₇S 
• 1416363-94-4 C₂₃H₁₉ClF₃N₃O₅S 
• 1341199-20-9 C₂₄H₂₄ClN₃O₅S 
• 1416363-96-6 C₂₄H₂₄ClN₃O₅S 
• 1341199-19-6 C₂₄H₂₄ClN₃O₅S 
• 1416363-97-7 C₂₂H₁₈Cl₃N₃O₅S 
• 1416363-98-8 C₂₂H₁₈Cl₃N₃O₅S 
• 1341199-22-1 C₂₂H₁₈Cl₃N₃O₅S 
• 1416364-00-5 C₂₂H₁₈BrCl₂N₃O₅S 
• 1416364-02-7 C₂₃H₁₈Cl₂N₄O₅S 

Relevant articles and documents

Identification of the novel N-phenylbenzenesulfonamide derivatives as potent HIV inhibitors

Searching for more safe and effective agents for HIV treatments is still an urgent topic worldwide. Based on our continuous modifications on the benzophenone derivatives as HIV-1 reverse transcriptase (RT) inhibitors, a new template bearing N-phenylbenzenesulfonamide (PBSA) structure was designed to enhance the interactions with HIV-1 RT. In this manuscript, a series of PBSA derivatives were synthesized and evaluated for their anti-HIV-1 activity. The preliminary test showed that these compounds were potent to inhibit wild-type HIV-1 with EC50 values ranging of 0.105-14.531 μmol/L. In particular, compound 13f not only has high anti-HIV-1 activity (0.108 μmol/L), but also possesses low toxicity with a TI value of 1816.6. Furthermore, the major interactions of the inhibitor 13f with HIV-1 RT were also investigated using the molecular modelling. Our discovered structure-activity relationships (SARs) of these analogues may serve as an important clue for further optimizations.