134282-68-1

Basic information

• Product Name: YRGDS
• Synonyms: TYR-ARG-GLY-ASP-SER;YRGDS;H-TYR-ARG-GLY-ASP-SER-OH
• CAS NO: 134282-68-1
• Molecular Formula: C24H36N8O10
• Molecular Weight: 596.59
• Mol File: 134282-68-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: YRGDS(CAS DataBase Reference)
• NIST Chemistry Reference: YRGDS(134282-68-1)
• EPA Substance Registry System: YRGDS(134282-68-1)

Safety Data

• Hazardous Substances Data: 134282-68-1(Hazardous Substances Data)

Usage

General Description

The chemical YRGDS is a peptide sequence consisting of the amino acids tyrosine (Y), arginine (R), glycine (G), aspartic acid (D), and serine (S). This specific sequence has been shown to have cell-adhesive properties and is commonly used in the development and research of biomaterials, tissue engineering, and drug delivery systems. YRGDS has been found to promote cell adhesion and proliferation, making it a valuable component in the design of materials for regenerative medicine and tissue repair. Additionally, the peptide has been explored for its potential in targeted drug delivery, as it can bind to specific cellular receptors and enhance the uptake of therapeutic agents. Overall, YRGDS plays a crucial role in the development of advanced biomedical materials and technologies.

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 

Relevant articles and documents

Protease-Sensitive Hydrogel Biomaterials with Tunable Modulus and Adhesion Ligand Gradients for 3D Vascular Sprouting

Biomaterial strategies focused on designing scaffolds with physiologically relevant gradients provide a promising means for elucidating 3D vascular cell responses to spatial and temporal variations in matrix properties. In this study, we present a photopolymerization approach, ascending photofrontal free-radical polymerization, to generate proteolytically degradable hydrogel scaffolds of poly(ethylene) glycol with tunable continuous gradients of (1) elastic modulus (slope of 80 Pa/mm) and uniform immobilized RGD concentration (2.06 ± 0.12 mM) and (2) immobilized concentration of the RGD cell-adhesion peptide ligand (slope of 58.8 μM/mm) and uniform elastic modulus (597 ± 22 Pa). Using a coculture model of vascular sprouting, scaffolds embedded with gradients of elastic modulus induced increases in the number of vascular sprouts in the opposing gradient direction, whereas RGD gradient scaffolds promoted increases in the length of vascular sprouts toward the gradient. Furthermore, increases in vascular sprout length were found to be prominent in regions containing higher immobilized RGD concentration.