134332-50-6 Usage
Description
Galanthamine-N-oxide is a metabolite of Galanthamine, which is a selective acetylcholinesterase inhibitor. It is an off-white powder in its chemical form.
Uses
Used in Pharmaceutical Industry:
Galanthamine-N-oxide is used as a pharmaceutical agent for its selective acetylcholinesterase inhibitory properties. This makes it a potential candidate for the treatment of neurodegenerative disorders, such as Alzheimer's disease, where the inhibition of acetylcholinesterase can help improve cognitive function and memory.
Used in Research Applications:
Galanthamine-N-oxide is also used in research settings to study the effects of acetylcholinesterase inhibition on various biological processes and to develop new drugs targeting this enzyme. Its role as a metabolite of Galanthamine provides insights into the mechanisms of action and potential therapeutic applications of this class of compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 134332-50-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,3,3 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 134332-50:
(8*1)+(7*3)+(6*4)+(5*3)+(4*3)+(3*2)+(2*5)+(1*0)=96
96 % 10 = 6
So 134332-50-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H21NO4/c1-18(20)8-7-17-6-5-12(19)9-14(17)22-16-13(21-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-,18?/m0/s1
134332-50-6Relevant articles and documents
Synthesis and in vitro evaluation of galanthamine derivatives for examination of nicotinic acetylcholine receptor system
Schildan, A.,Schirrmacher, R.,Samochocki, M.,Christner, C.,Mmaelicke, A.,Roesch, F.
, p. S247 - S249 (2001)
The synthesis and radioactive labeling of several galanthamine derivatives, 6-O-demethyl-6-O-fluoroethylgalanthamine, 10-N-demethyl-10-N-fluoroethylgalanthamine and N-methylgalanthaminium are reported. First in vitro evaluation were carried out to determine their properties as allosterically potentiating ligands of nicotinic receptors. N-methylgalanthaminium was found to be a promising candidate for further investigations.
Synthesis and structure-activity relationships of open D-Ring galanthamine analogues
Herlem, Denyse,Martin, Marie-Therese,Thal, Claude,Guillou, Catherine
, p. 2389 - 2391 (2003)
Open D-ring galanthamine analogues were prepared using ring-opening reactions of the quaternarized urethane or oxazolidine functions and were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potency.
