13435-22-8Relevant articles and documents
Identification and characterization of a potent antibacterial agent, NH125 against drug-resistant bacteria
Yamamoto, Kaneyoshi,Kitayama, Takashi,Ishida, Noriyasu,Watanabe, Takafumi,Tanabe, Hiroyuki,Takatani, Masahiro,Okamoto, Tadashi,Utsumi, Ryutaro
, p. 919 - 923 (2000)
New imidazole compounds were synthesized to develop a novel and effective antibacterial agent (1-benzyl-3-cetyl-2-methylimidazolium iodide, NH125). In vitro experiments demonstrated that NH125 effectively inhibited a number of different histidine protein
Method for alkylating N1-position of imidazole compound
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Paragraph 0017, (2020/02/29)
The present invention relates to a method for alkylating an N1-position of an imidazole compound and belongs to the technical field of organic synthesis. The method comprises the following steps: mixing an imidazole compound and carbonic ester with a molar ratio of 1:(1-2), conducting a heating reaction under a temperature of 80-140 DEG C under presence of aromatic hydrocarbons or a dipolar aprotic solvent and a strongly basic organic tertiary amine catalyst, and after reaction, directly conducting vacuum distillation or layering, and conducting vacuum distillation to obtain a N1 alkylated imidazole compound. The raw materials used in the method are non-toxic or low-toxic, the process is simple, reaction conditions are mild, and yield is high; and by-products in the reaction process are extremely few, environmental pollution is extremely small, and the preparation method is green and environmentally-friendly.
Regioselective C-H alkenylation of imidazoles and its application to the synthesis of unsymmetrically substituted benzimidazoles
Kim, Hyeongwoo,Hwang, Ye Ji,Han, Inhyuk,Joo, Jung Min
supporting information, p. 6879 - 6882 (2018/06/26)
A palladium-catalyzed C-H alkenylation of imidazoles has been developed. High C5 selectivity was achieved for C2-unsubstituted and C2-substituted imidazoles using oxygen and copper(ii) acetate, respectively, as oxidants. The obtained products were applied