134392-82-8

Basic information

• Product Name: 14.21-dihydroxy-5β.14β-pregnanedione-(3.20)
• CAS NO: 134392-82-8
• Molecular Weight: 348.483
• Mol File: 134392-82-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 14.21-dihydroxy-5β.14β-pregnanedione-(3.20)(CAS DataBase Reference)
• NIST Chemistry Reference: 14.21-dihydroxy-5β.14β-pregnanedione-(3.20)(134392-82-8)
• EPA Substance Registry System: 14.21-dihydroxy-5β.14β-pregnanedione-(3.20)(134392-82-8)

Safety Data

• Hazardous Substances Data: 134392-82-8(Hazardous Substances Data)

Upstream product

• 143-62-4 (+)-digitoxigenin 

Downstream Products

• 2402-25-7 21-acetoxy-5β-pregnane-3,20-dione 

Relevant articles and documents

Synthesis of 3β,14-Dihydroxy-5β,14β-pregnan-20-one C-3 Derivatives: Ozonolysis of Digitoxin and Digitoxigenin and their Derivatives followed by Zinc-Acid Reduction to the C-21 Methyl Ketone

Ozonolysis of digitoxin, digitoxin tetraacetate, digitoxin tetrakis-(2,2,2-trichloroethyl carbonate), digitoxigenin, digitoxigenin acetate, digitoxigenin hemisuccinate and digitoxigenin 2,2,2-trichloroethyl carbonate followed by treatment with excess of zinc in acetic acid gave either the corresponding 21-hydroxy ester after 5 min or the 21-methyl ketone after 20 h.This procedure is more efficient than methods previously reported for the conversion of the α,β-unsaturated γ-lactone into an acetyl group and is applicable to the cardiac glycosides directly to give 14β-hydroxypregnan-20-one derivatives.Acidic hydrolysis of 14,21-dihydroxy- and 14-hydroxy-3β-tris(digitoxosyloxy)-5β,14β-pregnan-20-one is reported.Structures are based on 1H and 13C NMR assignments.