1344112-08-8

Basic information

• Product Name: 2,6-dimethoxy-3-(3,4,5-trimethoxybenzoyl)phenyl chloroacetate
• Synonyms: 2,6-dimethoxy-3-(3,4,5-trimethoxybenzoyl)phenyl chloroacetate
• CAS NO: 1344112-08-8
• Molecular Weight: 424.835
• Mol File: 1344112-08-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,6-dimethoxy-3-(3,4,5-trimethoxybenzoyl)phenyl chloroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethoxy-3-(3,4,5-trimethoxybenzoyl)phenyl chloroacetate(1344112-08-8)
• EPA Substance Registry System: 2,6-dimethoxy-3-(3,4,5-trimethoxybenzoyl)phenyl chloroacetate(1344112-08-8)

Safety Data

• Hazardous Substances Data: 1344112-08-8(Hazardous Substances Data)

Upstream product

• 1440-81-9 2,6-dimethoxyphenyl chloroacetate 
• 118-41-2 Eudesmic acid 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 

Downstream Products

• 1344112-04-4 (3-hydroxy-2,4-dimethoxyphenyl)-(3,4,5-trimethoxyphenyl)methanone 

Relevant articles and documents

Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands

The majority of cancers detected every year are treated with anti-cancer compounds. Unfortunately, many tumors become resistant to antineoplastic drugs. One option is to use cocktails of compounds acting on different targets to try to overcome the resista

Synthesis and biological evaluation of phenstatin metabolites

Previous investigations on the incubation of phenstatin with rat and human microsomal fractions revealed the formation of nine main metabolites. The structures of eight of these metabolites have been now confirmed by synthesis and their biological properties have been reported. Eaton's reagent was utilized as a convenient condensing agent, allowing, among others, a simple multigram scale preparation of phenstatin. Synthesized metabolites and related compounds were evaluated for their antiproliferative activity in the NCI-60 cancer cell line panel, and for their effect on microtubule assembly. Metabolite 23 (2′-methoxyphenstatin) exhibited the most potent in vitro cytotoxic activity: inhibition of the growth of K-562, NCI-H322M, NCI-H522, KM12, M14, MDA-MB-435, NCI/ADR-RES, and HS 578T cell lines with GI50 values 50 = 3.2 μM vs 15.0 μM) and induced G2/M arrest in murine leukemia DA1-3b cells. The identification of this active metabolite led to the design and synthesis of analogs with potent in vitro cytotoxicity and inhibition of microtubule assembly.