134419-42-4

Basic information

• Product Name: Benzoic acid, 5-iodo-2,3-dimethoxy-
• CAS NO: 134419-42-4
• Molecular Formula: C9H9IO4
• Molecular Weight: 308.073
• Mol File: 134419-42-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 5-iodo-2,3-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-iodo-2,3-dimethoxy-(134419-42-4)
• EPA Substance Registry System: Benzoic acid, 5-iodo-2,3-dimethoxy-(134419-42-4)

Safety Data

• Hazardous Substances Data: 134419-42-4(Hazardous Substances Data)

Usage

Description

Benzoic acid, 5-iodo-2,3-dimethoxyis a chemical compound with the molecular formula C9H9IO4. It is a derivative of benzoic acid, which is commonly used as a food preservative. The 5-iodo-2,3-dimethoxy substitution on the benzene ring confers unique properties to this compound, making it useful in various chemical and pharmaceutical applications. Its chemical structure makes it a potential candidate for further synthesis into complex organic molecules, and it may also have potential biological activities due to its unique substitution pattern. Overall, benzoic acid, 5-iodo-2,3-dimethoxyis a versatile compound that can be used in a variety of scientific and industrial applications.

Uses

Used in Chemical Synthesis:
Benzoic acid, 5-iodo-2,3-dimethoxyis used as a building block for the synthesis of complex organic molecules. Its unique substitution pattern allows for further functionalization and modification, making it a valuable intermediate in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
Benzoic acid, 5-iodo-2,3-dimethoxyis used as a starting material for the development of new drugs. Its unique structure may confer novel biological activities, making it a promising candidate for the treatment of various diseases. Additionally, its potential as a prodrug or carrier molecule can be explored for targeted drug delivery and enhanced therapeutic efficacy.
Used in Food Preservation:
As a derivative of benzoic acid, benzoic acid, 5-iodo-2,3-dimethoxymay also be used as a food preservative. Its ability to inhibit the growth of microorganisms can help extend the shelf life of food products and maintain their quality and safety.
Used in Research and Development:
Benzoic acid, 5-iodo-2,3-dimethoxyis used as a research compound for studying the effects of halogen substitution on the properties and reactivity of benzoic acid derivatives. Its unique structure can provide insights into the design and synthesis of new molecules with improved properties and applications.

Upstream product

• 7396-66-9 5-iodo-2,3-dimethoxybenzaldehyde 
• 134528-76-0 2-(2,3-dimethoxy-5-iodophenyl)-4,5-dihydro-4,4-dimethyloxazole 
• 171805-85-9 methyl 5-iodo-2,3-dimethoxybenzoate 
• 259814-05-6 1-(2,3-dimethoxy-5-bromo)phenyl-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane 
• 72517-23-8 5-bromo-2,3-dimethoxybenzoic acid 
• 83131-08-2 methyl 5-bromo-2,3-dimethoxybenzoate 
• 107188-91-0 5-bromo-2,3-dimethoxybenzoic acid chloride 
• 259814-04-5 3-methyloxetane-3-methyl 2,3-dimethoxy-5-bromobenzoate 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 134419-48-0 5-bromo-2,3-dimethoxy-1-(1,3-dioxan-2-yl)benzene 
• 107189-00-4 2-(5-Bromo-2,3-dimethoxyphenyl)-4,5-dihydro-4,4-dimethyloxazole 
• 71295-21-1 5-bromo-2,3-dimethoxybenzaldehyde 
• 6342-70-7 3-methoxymethylsalicylate 
• 877-22-5 3-methoxysalicylic acid 

Downstream Products

• 107188-87-4 epidepride 
• 146445-07-0 (R)-(-)-2,3-dimethoxy-5-iodo-N-(2-pyrrolidinylmethyl)benzamide 
• 135441-69-9 5-iodo-2,3-dimethoxybenzoyl chloride 
• 146445-06-9 5-Iodo-2,3-dimethoxy-N-((R)-1-trityl-pyrrolidin-2-ylmethyl)-benzamide 

Relevant articles and documents

Asymmetric dearomative spirolactonization of naphthols using λ3-iodanes under chiral phase-transfer catalysis

The asymmetric phase-transfer catalytic effect of chiral Cinchona alkaloid-derived quaternary ammonium salts was investigated in the context of the λ3-iodane-mediated dearomative spirolactonization of naphthols. The scope and limitations of this methodology were evaluated using various substrates, which were converted into spirolactones in good yields and with enantiomeric excesses up to 58%.

A general method for the synthesis of raclopride, FLB 457 and epidepride and corresponding desmethyl-precursors

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Synthesis and 5-HT-3 receptor binding activity of 5-[125I]iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl]benzamide and its 5-halogen-2-alkoxyl homologues

(S)-5-Iodo-2,3-dimethoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (MIZAC) was prepared from 5-iodo-2,3-dimethoxybenzoyl chloride and (S)-3-aminoquinuclidine. [125I]Iodode-stannylation of its corresponding 5-tri-n-butyltin derivative gave [125I]-MIZAC at 1800 Ci/mmol. Binding of [125I]-MIZAC in rat entorhinal cortex revealed a K(D) of 1.37 ± 0.21 nM. A series of racemic 2-O-alkyl derivatives of MIZAC were prepared and 5-HT-3 receptor affinities were determined by inhibition of [125I]-MIZAC binding. Optimal affinity for the receptor was obtained with small, electron-withdrawing substituents in the aromatic 5-position and with bulky substituents in the 3-position. [125I]-MIZAC is a selective radioligand useful for in vitro identification of the 5-HT-3 receptor.