134431-68-8

Basic information

• Product Name: (13R,13aR)-13a-Chloromethyl-2,3,10,11-tetramethoxy-8-oxo-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-13-carboxylic acid
• Synonyms: (13R,13aR)-13a-Chloromethyl-2,3,10,11-tetramethoxy-8-oxo-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-13-carboxylic acid
• CAS NO: 134431-68-8
• Molecular Weight: 461.899
• Mol File: 134431-68-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (13R,13aR)-13a-Chloromethyl-2,3,10,11-tetramethoxy-8-oxo-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-13-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (13R,13aR)-13a-Chloromethyl-2,3,10,11-tetramethoxy-8-oxo-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-13-carboxylic acid(134431-68-8)
• EPA Substance Registry System: (13R,13aR)-13a-Chloromethyl-2,3,10,11-tetramethoxy-8-oxo-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-13-carboxylic acid(134431-68-8)

Safety Data

• Hazardous Substances Data: 134431-68-8(Hazardous Substances Data)

Upstream product

• 5653-42-9 3,4-dimethoxyhomophthalic anhydride 
• 91494-65-4 1-chloromethyl-6,7-dimethoxy-3,4-dihydro-isoquinoline 

Relevant articles and documents

REACTIONS OF α-CHLOROIMINES WITH HOMOPHTHALIC ANHYDRIDES. SYNTHESIS AND MOLECULAR STRUCTURE OF 3,3a-DIHYDROFUROISOQUINOLINE-1,5(4H,9bH)-DIONES, FURO-8,9,16,16a-TETRAHYDRO-1H,3H,11H-DIBENZOQUINOLIZINE-1,11-DIONES AND RELATED COMPOUNDS

The reaction of α-chloroimines 1-3, resp. 11 with homophthalic anhydrides 4 leads to the formation of the isoquinoline ring system incorporated in furoisoquinolinediones 8-10, resp. 13a-(chloromethyl)-8H-dibenzo-quinolizine-8-one-13-carboxylic acids 12.The latter compounds were converted into furodibenzoquinolizinediones 13 under basic conditions.NMR studies provided information concerning the relative configuration and the solution conformation of the various heterocycles obtained.The molecular structure of 8b and 12b was determined by X-ray analysis.