1344670-01-4Relevant articles and documents
Acidic triazoles as soluble guanylate cyclase stimulators
Roberts, R. Lee,Bradley, A. Paul,Bunnage, E. Mark,England, S. Katherine,Fobian, M. Yvette,Fox, N.A. David,Gymer, Geoff E.,Heasley, Steven E.,Molette, Jerome,Smith, Graham L.,Fairman, David,Schmidt, Michelle A.,Tones, Michael A.,Dack, Kevin N.
, p. 6515 - 6518 (2011/12/04)
A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF3 triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.