1345001-89-9Relevant articles and documents
Stable and orally bio-available pro-drugs of CPS11
Huo, Aihong,Zhang, Hesheng,Guan, Yongbiao,Zeng, Guanghuai,Chen, Yingwei,Li, Xingwen
, p. 6242 - 6244 (2011)
Stable and orally bio-available pro-drugs of CPS11 were synthesized. They are active on human umbilical vein endothelial cell proliferation assay and tube formation assay. The therapeutic efficacy and safety of 4 as a single agent or combined with Taxol in the treatment of MX-1 human breast cancer xenograft were evaluated. Compound 4 as a single agent failed to produce an anti-tumor activity, while it significantly enhanced antitumor potency of Taxol.