134511-53-8Relevant articles and documents
Synthesis of secasterol and 24-episecasterol and their toxicity for MCF-7 cells
Khripach,Zhabinskii,Gulyakevich,Konstantinova,Misharin, A. Yu.,Mekhtiev,Timofeev,Tkachev, Ya. V.
, p. 746 - 754 (2011/10/03)
The convergent synthesis of biosynthetic precursors of brassinosteroids with a Δ2-bond in cycle A-secasterol and 24-episecasterol-was performed. The key stages in the construction of the side chain in these compounds were the Julia olefination of the steroid 22-aldehyde followed by the Sharpless asymmetric dihydroxylation of the intermediate Δ22- olefin. The cytotoxicity of the synthesized compounds for breast carcinoma MCF-7 cells was assessed.