134579-47-8

Basic information

• Product Name: 2-IODO-ISONICOTINIC ACID METHYL ESTER
• Synonyms: 2-IODO-ISONICOTINIC ACID METHYL ESTER;methyl 2-iodoisonicotinate;m-2-Iict
• CAS NO: 134579-47-8
• Molecular Formula: C7H6INO2
• Molecular Weight: 263.03
• Mol File: 134579-47-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 305.6 °C at 760 mmHg
• Flash Point: 138.6 °C
• Appearance: /
• Density: 1.844 g/cm³
• Vapor Pressure: 0.000812mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Refrigerated.
• CAS DataBase Reference: 2-IODO-ISONICOTINIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODO-ISONICOTINIC ACID METHYL ESTER(134579-47-8)
• EPA Substance Registry System: 2-IODO-ISONICOTINIC ACID METHYL ESTER(134579-47-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 134579-47-8(Hazardous Substances Data)

Usage

General Description

2-IODO-ISONICOTINIC ACID METHYL ESTER is a chemical compound with the molecular formula C7H6INO2. It is commonly used in organic synthesis and pharmaceutical research due to its unique properties and potential applications. 2-IODO-ISONICOTINIC ACID METHYL ESTER is a derivative of isonicotinic acid and contains an iodine atom, which makes it useful for various chemical reactions and as a building block for the synthesis of more complex molecules. Its methyl ester group also enhances its solubility and stability, making it a versatile and valuable compound for research and development in the fields of chemistry and pharmaceuticals.

InChI:InChI=1/C7H6INO2/c1-11-7(10)5-2-3-9-6(8)4-5/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 58481-10-0 2-iodopyridine-4-carboxylic acid 
• 6313-54-8 2-chloroisonicotinic acid, 

Downstream Products

• 588702-68-5 2-trifluoromethyl-isonicotinic acid methyl ester 

Relevant articles and documents

Efficient copper-catalyzed trifluoromethylation of aromatic and heteroaromatic iodides: The beneficial anchoring effect of borates

Efficient copper-catalyzed trifluoromethylation of aromatic iodides was achieved with TMSCF3 in the presence of trimethylborate. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decomposition. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionalization of different aromatic and heteroaromatic iodides.

Imidazole derivatives

Novel imidazole derivatives are disclosed. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating neuronal activity and plasticity which makes them key players in mediating processes underlying development of CNS as well as learning and memory formation. These compounds are useful in the control or treatment of diseases mediated by this receptor.