1345853-44-2

Basic information

• Product Name: C₃₀H₂₈N₂O₂
• CAS NO: 1345853-44-2
• Molecular Weight: 448.565
• Mol File: 1345853-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₂₈N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₂₈N₂O₂(1345853-44-2)
• EPA Substance Registry System: C₃₀H₂₈N₂O₂(1345853-44-2)

Safety Data

• Hazardous Substances Data: 1345853-44-2(Hazardous Substances Data)

Upstream product

• 86-74-8 9H-carbazole 
• 52131-82-5 9-(oxiran-2-ylmethyl)-9H-carbazole 
• 1345853-50-0 1-(9H-carbazol-9-yl)-3-[(4-methylbenzyl)amino]propan-2-ol 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Carbazole-containing arylcarboxamides as BACE1 inhibitors

β-Secretase (BACE1) is widely recognized as a prime drug target for the treatment of Alzheimer's disease (AD). In this Letter, we report the synthesis and the BACE1 inhibitory activity of novel, variously substituted N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-arylcarboxamides. The best results have been obtained with the introduction of a 4-OMe substituent (IC50 = 3.8 μM) or a 3,4-dichloro substituent (IC50 = 2.5 μM) in the amidic aromatic ring. The blood-brain barrier penetration predictions resulted to be promising for this type of compounds. To better understand the structure-activity relationships (SAR) of the new derivatives, a docking study procedure has been applied exploiting different conformational and ionic states of BACE1.