1346019-43-9Relevant articles and documents
Synthesis, iron(III)-binding affinity and in vitro evaluation of 3-hydroxypyridin-4-one hexadentate ligands as potential antimicrobial agents
Xu, Bo,Kong, Xiao-Le,Zhou, Tao,Qiu, Di-Hong,Chen, Yu-Lin,Liu, Mu-Song,Yang, Rong-Hua,Hider, Robert C.
scheme or table, p. 6376 - 6380 (2011/12/02)
Iron is a critical element for the survival of bacteria. We have designed and synthesized two novel 3-hydroxypyridin-4-one hexadentate ligands with high affinity for iron(III), which disrupt bacterial iron absorption. Biological studies demonstrate that these two chelators have significant inhibitory effect against both Gram-positive and Gram-negative bacteria, and therefore have potential as antimicrobial agents.