134627-26-2

Basic information

• Product Name: 3-(diphenylhydroxymethyl)-2-(methylamino)naphthalene
• CAS NO: 134627-26-2
• Molecular Weight: 339.437
• Mol File: 134627-26-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(diphenylhydroxymethyl)-2-(methylamino)naphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(diphenylhydroxymethyl)-2-(methylamino)naphthalene(134627-26-2)
• EPA Substance Registry System: 3-(diphenylhydroxymethyl)-2-(methylamino)naphthalene(134627-26-2)

Safety Data

• Hazardous Substances Data: 134627-26-2(Hazardous Substances Data)

Upstream product

• 91-59-8 naphthalen-2-ylamine 
• 134627-20-6 N-(benzotriazol-1-ylmethyl)-2-naphthylamine 
• 119-61-9 benzophenone 
• 2216-67-3 2-N-methylaminonaphthalene 

Relevant articles and documents

Carbon Dioxide: A Reagent for the Simultaneous Protection of Nucleophilic Centers and the Activation of Alternative Locations to Electrophilic Attack. 17. Substitution of N-Methyl-1- and N-Methyl-2-naphthylamine and Side-Chain Functionalization of o-Toluidine

N-Methyl-1-naphthylamine is readily converted into a range of 2-substituted derivatives in one-pot sequences, using carbon dioxide for NH protection.Similarly, N-methyl-2-naphthylamine yields 3-substituted derivatives in the first direct preparation of 2,3-disubstituted naphthalenes.The intermediate lithium carbamates are further lithiated by tert-butyllithium at the 2-position for N-methyl-1-naphthylamine and at the 3-position for N-methyl-2-naphthylamine and then reacted with an electrophile; the products undergo acid-catalyzed decarboxylation during workup. o-Toluidine is converted into its methyl-functionalized derivatives in a similar way, except that 2 equiv of tert-butyllithium are used for the further lithiation of the intermediate lithium carbamate.