1346444-76-5

Basic information

• Product Name: N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinecarboxylic acid tert-butyl ester
• Synonyms: N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinecarboxylic acid tert-butyl ester
• CAS NO: 1346444-76-5
• Molecular Weight: 581.646
• Mol File: 1346444-76-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinecarboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinecarboxylic acid tert-butyl ester(1346444-76-5)
• EPA Substance Registry System: N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinecarboxylic acid tert-butyl ester(1346444-76-5)

Safety Data

• Hazardous Substances Data: 1346444-76-5(Hazardous Substances Data)

Upstream product

• 3958-60-9 2-nitrophenylmethyl bromide 
• 1666-02-0 2-hydroxy-4,6-dimethylbenzaldehyde 
• 103-04-8 (phenylthio)acetic acid 
• 870-46-2 t-butoxycarbonylhydrazine 
• 1346444-72-1 N'-(2-phenylsulfanylacetyl)hydrazinecarboxylic acid tert-butyl ester 
• 1346444-74-3 N'-(2-phenylsulfonylacetyl)hydrazinecarboxylic acid tert-butyl ester 
• 1346444-69-6 2,4-dimethyl-6-(2-nitrobenzyloxy)benzaldehyde 

Downstream Products

• 1346444-82-3 C₂₉H₃₄N₂O₆S₂ 
• 1332707-91-1 3-benzenesulfonyl-5,7-dimethylchromen-2-one 
• 1346444-92-5 [(1S)-1-(N'-{2-benzenesulfonyl-3-[2,4-dimethyl-6-(2-nitrobenzyloxy)phenyl]-(E)-acryloyl}hydrazinocarbonyl)-3-carbamoylpropyl]carbamic acid tert-butyl ester 
• 1346444-95-8 C₅₂H₇₀N₁₀O₁₆S 
• 1346444-87-8 C₈₄H₁₁₄N₁₈O₂₄S₂ 
• 1346444-80-1 C₃₆H₃₉N₃O₈S₂ 

Relevant articles and documents

Development of UV-responsive catch-and-release system of a cysteine protease model peptide

Cysteine proteases are attractive drug targets due to their involvement in a wide variety of diseases. To evaluate the potential of a particular protease as a drug target, use of a reagent that controls activity of the protease is indispensable. In this context, we have developed a catch-and-release reagent that first forms a covalent bond with the active center thiol of a cysteine protease to suppress its activity and then is removed by UV-irradiation to release the parent active protease. In this paper, the design and synthesis of a catch-and-release reagent of thiols are described. Its application to caging (catch) and UV-induced uncaging (release) of a model peptide derived from an active site of caspase-9 and introduction of a recognition moiety on the reagent are also reported.