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1346702-53-1

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1346702-53-1 Usage

General Description

Methyl 6-bromO-2-isopropyl-2H-indazole-4-carboxylate is a chemical compound with the molecular formula C13H15BrN2O2. It is an indazole derivative with a bromine substitution at the 6 position and a methyl ester group at the 4 position. Methyl 6-broMo-2-isopropyl-2H-indazole-4-carboxylate has potential applications in medicinal chemistry and pharmaceutical research, as it may exhibit biological activities and properties that could be useful in drug development. It is important to handle and use this compound with caution, as it may have hazardous properties and should only be used by trained professionals in a controlled laboratory setting.

Check Digit Verification of cas no

The CAS Registry Mumber 1346702-53-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,6,7,0 and 2 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1346702-53:
(9*1)+(8*3)+(7*4)+(6*6)+(5*7)+(4*0)+(3*2)+(2*5)+(1*3)=151
151 % 10 = 1
So 1346702-53-1 is a valid CAS Registry Number.

1346702-53-1Downstream Products

1346702-53-1Relevant articles and documents

18F-Labeled PET Probe Targeting Enhancer of Zeste Homologue 2 (EZH2) for Cancer Imaging

Yu, Lihai,Despotovic, Nikola,Kovacs, Michael S.,Pin, Christopher L.,Luyt, Leonard G.

supporting information, p. 334 - 340 (2019/03/11)

The enzyme enhancer of zeste homologue 2 (EZH2) plays a catalytic role in histone methylation (H3K27me3), one of the epigenetic modifications that is dysregulated in cancer. The development of a positron emission tomography (PET) imaging agent targeting E

Identification of potent, selective, cell-Active inhibitors of the histone lysine methyltransferase EZH2

Verma, Sharad K.,Tian, Xinrong,Lafrance, Louis V.,Duquenne, Céline,Suarez, Dominic P.,Newlander, Kenneth A.,Romeril, Stuart P.,Burgess, Joelle L.,Grant, Seth W.,Brackley, James A.,Graves, Alan P.,Scherzer, Daryl A.,Shu, Art,Thompson, Christine,Ott, Heidi M.,Van Aller, Glenn S.,MacHutta, Carl A.,Diaz, Elsie,Jiang, Yong,Johnson, Neil W.,Knight, Steven D.,Kruger, Ryan G.,McCabe, Michael T.,Dhanak, Dashyant,Tummino, Peter J.,Creasy, Caretha L.,Miller, William H.

supporting information, p. 1091 - 1096 (2013/02/23)

The histone H3-lysine 27 (H3K27) methyltransferase EZH2 plays a critical role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. As part of a drug discovery program targeting EZH2, we have identified highly potent, selective, SAM-competitive, and cell-Active EZH2 inhibitors, including GSK926 (3) and GSK343 (6). These compounds are small molecule chemical tools that would be useful to further explore the biology of EZH2.

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