134672-70-1

Basic information

• Product Name: 3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID
• Synonyms: 3-(2',4'-DIFLUOROPHENYL)PROPIONIC ACID;3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID;2,4-Difluorobenzenepropanoic acid;Benzenepropanoic acid, 2,4-difluoro-;3-(2,4-Difluorophenyl)propionic acid 97%
• CAS NO: 134672-70-1
• Molecular Formula: C₉H₈F₂O₂
• Molecular Weight: 186.16
• Product Categories: C9;Carbonyl Compounds;Carboxylic Acids
• Mol File: 134672-70-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 104-108 °C(lit.)
• Boiling Point: 272℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.312
• Vapor Pressure: 0.00309mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: 2-8°C
• PKA: 4.63±0.10(Predicted)
• CAS DataBase Reference: 3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID(134672-70-1)
• EPA Substance Registry System: 3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID(134672-70-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-39-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 134672-70-1(Hazardous Substances Data)

Usage

General Description

3-(2,4-Difluorophenyl)propionic acid is a chemical compound which consists of a propionic acid molecule with a phenyl ring attached to it. The phenyl ring contains two fluorine atoms in the para position, resulting in a difluorophenyl group. 3-(2,4-DIFLUOROPHENYL)PROPIONIC ACID is often used in organic synthesis for its ability to add a difluorophenyl moiety to various molecules. It can also be used as an intermediate in the production of pharmaceuticals or agrochemicals. Overall, 3-(2,4-difluorophenyl)propionic acid is a versatile chemical with applications in various industries.

InChI:InChI=1/C9H8F2O2/c10-7-3-1-6(8(11)5-7)2-4-9(12)13/h1,3,5H,2,4H2,(H,12,13)

Upstream product

• 94977-52-3 2,4-Difluorocinnamic acid 
• 134672-69-8 ethyl 3-(2,4-difluorophenyl)propanoate 

Downstream Products

• 162549-39-5 3-(2,4-difluorophenyl)propionyl chloride 
• 162548-73-4 4,6-difluoroindan-1-one 
• 1065584-71-5 1-(4-(2-(5-amino-2-(furan-2-yl)-7H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)piperazin-1-yl)-3-(2,4-difluorophenyl)propan-1-one 
• 957204-67-0 3-(2,4-difluorophenyl)propan-1-ol 
• 849488-10-4 (4R,5S)-3-[3-(2,4-difluoro-phenyl)-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 924623-91-6 N-[4-(4-Chloro-phenyl)-thiazol-2-yl]-3-(2,4-difluoro-phenyl)-propionamide 
• 1333405-94-9 5-(5-(2,4-difluorphenylethyl)-1,3,4-oxadiazol-2-yl)benzimidazole 
• 1333406-15-7 5-(5-(2,4-difluorphenylethyl)-1,3,4-thiadiazol-2-yl)benzimidazol 

Relevant articles and documents

3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted-2H-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.

Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity

The design of rigid cyclic analogues derived from cinnamamide 1, (E)-N-cyclopropyl-3-(3-fluorophenyl)prop-2-enamide, and β-methylcinnamamide 2, (E)-N-cyclopropyl-3-(3-fluorophenyl)but-2-enamide, has led to the discovery of the potent, centrally acting muscle relaxant (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 17. Compound 17 also possesses potent antiinflammatory and analgesic activity. This paper describes the synthesis and the muscle relaxant, antiinflammatory, and analgesic structure-activity relationships of 17 and 67 of its analogues. Compound 17 has been taken into phase I clinical trials.

Bicyclic amide derivatives and their use as muscle relaxants

Novel compounds of formula (1) together with their salts and solvates have a number of uses in medicine, in particular as central muscle relaxants.