134703-22-3

Basic information

• Product Name: 2-(4-aminophenyl)pyrrole
• Synonyms: 2-(4-aminophenyl)pyrrole
• CAS NO: 134703-22-3
• Molecular Weight: 158.203
• Mol File: 134703-22-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-aminophenyl)pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-aminophenyl)pyrrole(134703-22-3)
• EPA Substance Registry System: 2-(4-aminophenyl)pyrrole(134703-22-3)

Safety Data

• Hazardous Substances Data: 134703-22-3(Hazardous Substances Data)

Upstream product

• 38063-81-9 p-aminoacetophenone oxime 
• 74-86-2 acetylene 
• 586-78-7 para-nitrophenyl bromide 
• 109-97-7 pyrrole 
• 106-47-8 4-chloro-aniline 

Relevant articles and documents

Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities

This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.

PYRROLES FROM KETOXIMES AND ACETYLENE. 44. METHYL ARYL KETOXIMES WITH REACTIVE SUBSTITUENTS

The Trofinov reaction was extended to methyl aryl ketoximes with substituents in the benzene ring that are unstable with respect to the action of a strongly basic medium.The corresponding pyrroles and their 1-vinyl derivatives were obtained. 4-Nitroacetophenone oxime, from which only 2-phenyl- and 1-phenyl-2-phenylpyrrole were obtained, and 4-bromoacetophenone oxime, the reaction of which leads to the formation of 1-vinyl-2-(4-vinyloxyphenyl)pyrrole in addition to the principal 2-(4-bromophenyl)pyrrole, constituted exceptions.