1347750-72-4

Basic information

• Product Name: m-PEG6-acid
• Synonyms: m-PEG6-acid;2,5,8,11,14,17-hexaoxaicosan-20-oic acid;mPEG6-COOH;2,5,8,11,14,17-hexaoxaicosan-20-oic acid(WXC06947)
• CAS NO: 1347750-72-4
• Molecular Formula: C14H28O8
• Molecular Weight: 324.36732
• Mol File: 1347750-72-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 431.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.109±0.06 g/cm3(Predicted)
• Solubility: Soluble in Water
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: m-PEG6-acid(CAS DataBase Reference)
• NIST Chemistry Reference: m-PEG6-acid(1347750-72-4)
• EPA Substance Registry System: m-PEG6-acid(1347750-72-4)

Safety Data

• Hazardous Substances Data: 1347750-72-4(Hazardous Substances Data)

Usage

Description

m-PEG6-acid is a polyethylene glycol (PEG) linker with a terminal carboxylic acid group. It is designed to facilitate the formation of stable amide bonds with primary amine groups in the presence of suitable activators, such as EDC or HATU. The hydrophilic PEG spacer enhances solubility in aqueous media, making it a versatile molecule for various applications.

Uses

Used in Pharmaceutical Industry:
m-PEG6-acid is used as a PEGylation agent for improving the solubility, stability, and bioavailability of therapeutic proteins and peptides. The formation of stable amide bonds with primary amine groups allows for the attachment of PEG moieties, which can reduce immunogenicity, increase half-life, and improve the overall pharmacokinetic profile of the drug.
Used in Drug Delivery Systems:
m-PEG6-acid is used as a component in the design and synthesis of targeted drug delivery systems. The PEG spacer can be functionalized with various targeting ligands, allowing for specific interactions with cellular receptors or other biological targets. This targeted approach can enhance the selectivity and efficacy of drug delivery, reducing off-target effects and improving therapeutic outcomes.
Used in Bioconjugation:
m-PEG6-acid is used as a bioconjugation agent for the covalent attachment of biologically active molecules, such as peptides, proteins, or small molecules, to other biomolecules or surfaces. The stable amide bond formation enables the creation of conjugates with well-defined structures and properties, which can be tailored for specific applications in research, diagnostics, or therapeutics.
Used in Material Science:
m-PEG6-acid can be utilized in the development of hydrogels, micelles, or other biocompatible materials for various applications, such as tissue engineering, wound healing, or controlled release of bioactive agents. The hydrophilic PEG spacer provides improved water solubility and biocompatibility, while the terminal carboxylic acid allows for further functionalization or crosslinking with other molecules.