134779-41-2Relevant articles and documents
Enzyme-catalysed approach to the preparation of triazole antifungals: synthesis of (-)-genaconazole
Acetti, Daniela,Brenna, Elisabetta,Fuganti, Claudio,Gatti, Francesco G.,Serra, Stefano
experimental part, p. 2413 - 2420 (2010/03/24)
The work describes a new enzyme-mediated approach to optically active epoxide (2R,3S)-6, which is an important key intermediate in the preparation of single enantiomers of chiral azole antifungals. The conversion of (2R,3S)-6 into (-)-genaconazole is reported as an example of its synthetic relevance.
Asymmetric synthesis of SM-9164, a biologically active enantiomer of antifungal agent SM-8668
Miyauchi, Hiroshi,Nakamura, Toshio,Ohashi, Naohito
, p. 2625 - 2632 (2007/10/03)
SM-9164, a biologically active enantiomer of antifungal agent SM-8668, was prepared by asymmetric synthesis in 10 steps in 13% overall yield from commercially available 2-chloro-1-(2,4-difluorophenyl)ethanone. The crucial steps were Katsuki-Sharpless asymmetric epoxidation of the (E)-allylic alcohol and epimerization of the erythro-sulfone to the desired threo-isomer under basic conditions.
Optical resolution of dl-threo-2-(2,4-difluorophenyl)-2-[1-(methylthio)ethyl]oxirane: Its application to the synthesis of SM-9164, a biologically active enantiomer of antifungal agent SM-8668
Miyauchi,Ohashi
, p. 3591 - 3598 (2007/10/03)
A racemate of threo-2-(2,4-difluorophenyl)-2-[1-(methylthio)ethyl]oxirane was separated into two enantiomers by reaction with a chiral carboxylic acid, followed by separation of the resultant diastereomers, hydrolysis of the ester, and dehydration of the 1,2-diol to the oxirane. This new optical resolution method was applied to the synthesis of SM-9164, a biologically active enantiomer of antifungal agent SM-8668. Thus, the optically active isomer of SM-8668 was prepared efficiently in eight steps from m-difluorobenzene.