134792-45-3

Basic information

• Product Name: 5-FLUOROISATOIC ANHYDRIDE
• Synonyms: 5-FLUOROISATOIC ANHYDRIDE;6-FLUORO ISATIN ANHYDRIDE;2H-1,3-Benzoxazine-2,4(3H)-dione, 6-fluoro-;6-Fluoro-2H-benzo[e][1,3]oxazine-2,4(3H)-dione
• CAS NO: 134792-45-3
• Molecular Formula: C8H4FNO3
• Molecular Weight: 181.12
• Mol File: 134792-45-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 192-196℃
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.502g/cm³
• Refractive Index: 1.56
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: DMSO
• PKA: 9.71±0.20(Predicted)
• CAS DataBase Reference: 5-FLUOROISATOIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUOROISATOIC ANHYDRIDE(134792-45-3)
• EPA Substance Registry System: 5-FLUOROISATOIC ANHYDRIDE(134792-45-3)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 134792-45-3(Hazardous Substances Data)

Usage

Description

5-FLUOROISATOIC ANHYDRIDE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its anhydride functional group and a fluorine atom at the 5th position, which contributes to its unique reactivity and properties in chemical reactions.

Uses

Used in Pharmaceutical Industry:
5-FLUOROISATOIC ANHYDRIDE is used as a key intermediate for the development of insulin secretagogues, which are essential in the treatment of diabetes. Its unique structure allows for the creation of compounds that can stimulate insulin production and secretion, helping to regulate blood sugar levels in patients.
5-FLUOROISATOIC ANHYDRIDE is also used as a building block in the synthesis of HCV (Hepatitis C Virus) polymerase inhibitors. These inhibitors play a vital role in the treatment of Hepatitis C by disrupting the virus's ability to replicate, thereby reducing the viral load and aiding in the recovery process.
In addition to its applications in diabetes and Hepatitis C treatments, 5-FLUOROISATOIC ANHYDRIDE is utilized in the development of anxiolytic agents. These agents are designed to alleviate anxiety and related disorders by targeting specific receptors in the brain, providing a more targeted and effective treatment option for patients suffering from anxiety.
Furthermore, 5-FLUOROISATOIC ANHYDRIDE is employed in the synthesis of other bioactive compounds, which have potential applications in various therapeutic areas. Its versatility as a pharmaceutical intermediate makes it a valuable asset in the development of new and innovative medications to address a wide range of health conditions.

InChI:InChI=1/C8H4FNO3/c9-4-2-1-3-5-6(4)7(11)13-8(12)10-5/h1-3H,(H,10,12)

Upstream product

• 391-92-4 methyl 5-fluoro-2-hydroxybenzoate 
• 345-16-4 5-fluoro-2-hydroxybenzoic acid 
• 56874-97-6 5-fluoro-2-hydroxybenzamide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 16499-56-2 6-fluoro-3,4-dihydroquinazolin-4-one 
• 147005-03-6 10-(3-benzyl-1,2,4-oxadiazol-5-yl)-3-fluoro-9H-imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine 
• 147004-95-3 4-fluoro-2-(1H-1,2,4-triazol-3-yl)aniline 

Relevant articles and documents

The Light Emitter of the 2-Coumar-anone Chemiluminescence: Theoretical and Experimental Elucidation of a Possible Model for Bioluminescent Systems

The bioluminescence reaction of many biological subspecies, most notably fireflies, forms dioxetanone derivatives as high-energy intermediates. The thermal instability of dioxetanones complicates understanding of the transition from the ground state to th

ANTIBACTERIAL COMPOUNDS HAVING BROAD SPECTRUM OF ACTIVITY

The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.