134807-23-1

Basic information

• Product Name: 1H-Imidazole-1-acetic acid, phenylmethyl ester
• CAS NO: 134807-23-1
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.239
• Mol File: 134807-23-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-1-acetic acid, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-1-acetic acid, phenylmethyl ester(134807-23-1)
• EPA Substance Registry System: 1H-Imidazole-1-acetic acid, phenylmethyl ester(134807-23-1)

Safety Data

• Hazardous Substances Data: 134807-23-1(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 79-04-9 chloroacetyl chloride 
• 100-51-6 benzyl alcohol 
• 5437-45-6 Benzyl bromoacetate 

Downstream Products

• 22884-10-2 imidazol-1-ylacetic acid 
• 141264-16-6 N-<(benzyloxycarbonyl)methyl>-N-formylformamide 

Relevant articles and documents

Synthesis and regioselective hydrolysis of 2-imidazol-1-ylsuccinic esters

(±)-2-Imidazol-1-ylsuccinic esters were synthesized by thermal addition of imidazole to either fumaric or maleic esters. Acceleration of the reaction was achieved, in some cases, using microwave heating. These esters underwent an easy regioselective hydrolysis, under neutral conditions, to give the corresponding half-esters: (±)-3-(alkoxycarbonyl)-2-imidazol-1-ylpropionic acids, through either BAC3 or BAL1 mechanisms. Kinetic studies in H2O and D2O as well as 18O and 17O labeling experiments supported the proposed mechanism. The results of these hydrolyses, which depended on the nature of the alcohol moiety, were compared with those obtained with some imidazol-1-ylacetate analogues or with (±)-2-pyrazol-1-yl- and benzimidazol-1-ylsuccinic esters. In general, imidazolylsuccinic esters hydrolyzed faster than the homologous derivatives from pyrazole or benzimidazole.

RETROVIRAL PROTEASE INHIBITING COMPOUNDS

None