1348480-53-4Relevant articles and documents
Substrate structural effects in yttrium(III)-catalyzed hydroamination/ cyclizations of 1,2-disubstituted and 1,1,2-trisubstituted aminoalkenes terminated by 2-(phenyl) and 2-(2-heteroarenyl) groups
Jiang, Tao,Huynh, Khoi,Livinghouse, Tom
, p. 193 - 196 (2013)
A series of 2-phenyl- and 2-(2-heteroarenyl)-bearing amines possessing 1,2-disubstituted and 1,1,2-trisubststuted alkenes have been evaluated in intramolecular hydroaminations catalyzed by Y[N(TMS)(1. Aminoalkenes possessing a terminal 2-(5-trimethylsilyl)thienyl group exhibited substantially enhanced reactivity compared to their 2-(phenyl)-containing counterparts. Cyclization efficiencies imparted by the 2-[(5-trimethylsilyl)furanyl] substituent were comparable or only slightly better than those obtained with the simple the 2-(phenyl) group. Georg Thieme Verlag Stuttgart · New York.