1349631-59-9

Basic information

• Product Name: C₂₃H₂₃Cl₂N₅O₂
• CAS NO: 1349631-59-9
• Molecular Weight: 472.374
• Mol File: 1349631-59-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₃Cl₂N₅O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₃Cl₂N₅O₂(1349631-59-9)
• EPA Substance Registry System: C₂₃H₂₃Cl₂N₅O₂(1349631-59-9)

Safety Data

• Hazardous Substances Data: 1349631-59-9(Hazardous Substances Data)

Upstream product

• 2040-05-3 2,6 dichloroacetophenone 
• 53066-19-6 1-(2',6'-dichlorophenyl)-ethanol 
• 1175296-47-5 furo[3,2-c]pyridin-7-ol 
• 1175300-09-0 C₁₅H₁₁BrCl₂N₂O₂ 
• 1175300-08-9 C₁₅H₉BrCl₂N₂O₄ 
• 1175296-48-6 6-nitrofuro[3,2-c]pyridin-7-ol 
• 603300-96-5 7-bromofuro[3,2-c]pyridine 
• 26956-43-4 5H-furo[3,2-c]pyridin-4-one 

Relevant articles and documents

Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases

A series of novel 6-aminofuro[3,2-c]pyridines as kinase inhibitors is described, most notably, OSI-296 (6). We discuss our exploration of structure-activity relationships and optimization leading to OSI-296 and disclose its pharmacological activity against cMET and RON in cellular assays. OSI-296 is a potent and selective inhibitor of cMET and RON kinases that shows in vivo efficacy in tumor xenografts models upon oral dosing and is well tolerated.