1350327-71-7Relevant articles and documents
Synthesis and SAR of 2-Phenoxypyridines as novel c-Jun N-terminal kinase inhibitors
Song, Xinyi,Chen, Weimin,Lin, Li,Ruiz, Claudia H.,Cameron, Michael D.,Duckett, Derek R.,Kamenecka, Theodore M.
, p. 7072 - 7075 (2012/01/06)
The design and synthesis of a novel series of c-jun N-terminal kinase (JNK3) inhibitors is described. The development and optimization of the 2-phenoxypyridine series was carried out from an earlier pyrimidine series of JNK1 inhibitors. Through the optimization of the scaffold 2, several potent compounds with good in vivo profiles were discovered.
