135040-88-9Relevant articles and documents
Total synthesis of ailanthoidol, egonol, and related analogues
Duan, Xin-Fang,Shen, Gang,Zhang, Zhan-Bin
experimental part, p. 1181 - 1187 (2010/06/12)
Efficient and general synthetic protocols were developed for the total synthesis of ailanthoidol, egonol, and some related analogues. The key transformations describe here involve a two-step construction of the benzofuran and a Sonogashira coupling, and proved to be convenient and effective, starting from readily available reagents.
A new synthesis of the benzofuran adenosine antagonist XH-14
Hutchinson, Sally A.,Luetjens, Henning,Scammells, Peter J.
, p. 3081 - 3084 (2007/10/03)
5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzo[b]furan-3 -carbaldehyde (XH-14, 1) has been reported to be a potent A1 adenosine antagonist. We have developed an efficient synthesis of this compound that should prove valuable for further structure-activity studies. The synthesis incorporates optimised methodology for the selective protection of a hydroxyl group and the ortho-bromination of a phenol.
Naturally Occurring Benzofuran: Isolation, Structure Elucidation and Total Synthesis of 5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzofurancarbaldehyde, a Novel Adenosine A1 Receptor Ligand Isolated from Salvia miltior
Yang, Zhen,Hon, Po Ming,Chui, Kuk Ying,Xu, Zun Le,Chang, Hson Mou,et al.
, p. 2061 - 2064 (2007/10/02)
A naturally occurring benzofuran, namely 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzofurancarbaldehyde was isolated from the roots of S. miltiorrhiza Bunge "Danshen".Its structure was established by means of spectroscopic metho
